2006
DOI: 10.1111/j.1365-3083.2006.01843.x
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Abstract: Trypanosoma cruzi‐infected children was treated with benznidazole (Bz) during the early‐indeterminate disease (E‐IND) and the cytokine pattern of innate and adaptive immune compartments were evaluated prior to the treatment and 1 year after it. At first, we observed that the ex vivo cytokine profile of circulating leukocytes from E‐IND (n = 6) resembled the one observed for healthy schoolchildren (n = 7). Additionally, in vitro stimulation with T. cruzi antigens drove the E‐IND cytokine pattern toward a mixed … Show more

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Cited by 40 publications
(61 citation statements)
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“…There is a general consensus that the host immune response plays a pivotal role in the adverse events caused upon the massive antigen release triggered by trypanocidal agents during treatment (Sathler-Avelar et al 2006). With this in mind, our results show that hypnophilin display a non-cytotoxic antiproliferative activity on PBMC stimulated with PHA, suggesting that, besides its trypanocidal activity, hypnophilin can eventually reduce tissue damage by interfering with the proliferation of cells involved with the immune response.…”
Section: Discussionmentioning
confidence: 49%
“…There is a general consensus that the host immune response plays a pivotal role in the adverse events caused upon the massive antigen release triggered by trypanocidal agents during treatment (Sathler-Avelar et al 2006). With this in mind, our results show that hypnophilin display a non-cytotoxic antiproliferative activity on PBMC stimulated with PHA, suggesting that, besides its trypanocidal activity, hypnophilin can eventually reduce tissue damage by interfering with the proliferation of cells involved with the immune response.…”
Section: Discussionmentioning
confidence: 49%
“…Previous investigations using humans and experimental models have demonstrated the importance of the host immune system in the efficacy of chemotherapeutic treatments against parasitic diseases (31,34). In the present work, we investigated the effects of T-or B-lymphocyte deprivation on the anti-T. BZ is currently the most frequently available drug for the treatment of Chagas' disease in countries where it is endemic.…”
Section: Discussionmentioning
confidence: 99%
“…However, little is known about the influence of host parameters on therapeutic failures. One of the major factors potentially influencing the efficacy of treatment for Chagas' disease is the possible cooperative action between the drug effects and the host immunological response, which is particularly important in the context of immunosuppressed patients (3,21,24,31,34).…”
mentioning
confidence: 99%
“…A majority of the patients that progress to the chronic phase remains clinically asymptomatic for many years, with no clinical, radiological or electrocardiographic manifestations of cardiac or digestive involvement. These conditions characterise the initial stage of the indeterminate form, known as earlyindeterminate disease, which is usually detected in infected children and adolescents, and late-indeterminate disease, generally observed in infected adults (SathlerAvelar et al 2003, Vitelli-Avelar et al 2006. Approximately 30-40% of infected individuals progress to disease associated with cardiac and/or digestive symptoms (Umezawa et al 2000).…”
mentioning
confidence: 99%