Benzalkonium Chloride Accelerates the Formation of the Amyloid Fibrils of Corneal Dystrophy-associated Peptides

Kato, Yusuke; Yagi, Hisashi; Kaji, Yuichi; Oshika, Tetsuro; Goto, Yuji

doi:10.1074/jbc.m113.477695

Cited by 14 publications

(10 citation statements)

References 43 publications

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“…This sharp inflection point is most likely due to the formation of BAC micelles. This value is in good agreement with earlier reports . This uncommon behavior in SERS enhancement may be explained, as shown next, by micelle formation.…”

Section: Resultssupporting

confidence: 93%

Surface‐enhanced Raman scattering as a tool to study cationic surfactants exhibiting low critical micelle concentration

Mathioudakis

Beobide

Bokias

et al. 2019

J Raman Spectroscopy

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The collection of surface‐enhanced Raman scattering (SERS) by silver nanocolloids was used to identify the critical micelle concentration (CMC) of three cationic surfactants in 0.5‐M NaCl solutions: hexadecyltrimethylammonium bromide, dodecyltrimethylammonium bromide, and benzalkonium chloride. Despite structural similarity between the three test surfactans, differences of the shape and size of the respective micelles affected the corresponding SERS signals. The CMC values determined by this method agreed with the respective values measured by conventional methods, including fluorescence probing and electrical conductivity measurements. The potential for the application of SERS technique for low CMC determination without surface modification of silver nanoparticles by a Raman‐active molecule was also demonstrated.

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Section: Resultssupporting

confidence: 93%

Surface‐enhanced Raman scattering as a tool to study cationic surfactants exhibiting low critical micelle concentration

Mathioudakis

Beobide

Bokias

et al. 2019

J Raman Spectroscopy

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“…6a). 35,38,56 This correlation establishes that, combined with moderate denaturation effects on proteins, various detergents close to the CMC concentration accelerate fibrillation. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 21 were taken from Kato et al, 56 in which the number after BAC represented the length of alkyl chains.…”

Section: Resultsmentioning

confidence: 74%

“…35,38,56 This correlation establishes that, combined with moderate denaturation effects on proteins, various detergents close to the CMC concentration accelerate fibrillation. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 21 were taken from Kato et al, 56 in which the number after BAC represented the length of alkyl chains. The values for lysophosphatidic acid (LPA) with β2m were from Pal-Gabor et al 38 Furthermore, disordered proteins or peptides with no significant conformation in the absence of detergents (e.g., keratoepithelin, Aβ, or K3) indicated that the interactions between disordered proteins with detergent molecules slightly below CMC were directly responsible for initiating a fibrillation pathway.…”

Section: Resultsmentioning

confidence: 74%

Supersaturation-Limited and Unlimited Phase Spaces Compete to Produce Maximal Amyloid Fibrillation near the Critical Micelle Concentration of Sodium Dodecyl Sulfate

Ishii

Hata

et al. 2015

Langmuir

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Although various natural and synthetic compounds have been shown to accelerate or inhibit the formation of amyloid fibrils, the mechanisms by which they achieve these adverse effects in a concentration-dependent manner currently remain unclear. Sodium dodecyl sulfate (SDS), one of the compounds that has adverse effects on fibrillation, is the most intensively studied. Here we examined the effects of a series of detergents including SDS on the amyloid fibrillation of β2-microglobulin at pH 7.0, a protein responsible for dialysis-related amyloidosis. In all the detergents examined (i.e., SDS, sodium decyl sulfate, sodium octyl sulfate, and sodium deoxycholate), amyloid fibrillation was accelerated and inhibited at concentrations near the critical micelle concentration (CMC) and higher than CMC, respectively. The most stable conformation changed from monomers with a β-structure to amyloid fibrils with a β-structure and then to α-helical complexes with micelles with an increase in detergent concentrations. These results suggest that competition between supersaturation-limited fibrillation and unlimited mixed micelle formation between proteins and micelles underlies the detergent concentration-dependent complexity of amyloid fibrillation.

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“…The latter requires that the amount of BAC added be above the critical micelle concentration (CMC). Although the quantities used in the nasal formulations are not specified, the allowable range of BAC in nasal formulations, by USP 34-NF 29 standards, is 0.002–0.02 % w/v, which could allow for micelle formation since the CMC of BAC is 0.0035 % w/v [ 14 ]. Regardless of micelle formation or not, the addition of the cationic surfactant lowers the surface tension at the surface-to-air interface.…”

Section: Resultsmentioning

confidence: 99%

Surface tension examination of various liquid oral, nasal, and ophthalmic dosage forms

Han

Woghiren

Priefer

2016

Chemistry Central Journal

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Surface tension at the surface-to-air interface is a physico-chemical property of liquid pharmaceutical formulations that are often overlooked. To determine if a trend between surface tension and route of administration exists, a suite of oral, nasal, and ophthalmic drug formulations were analyzed. The surface tension at the surface-to-air interface of the oral formulations studied were in or above the range of the surface tension of gastric, duodenum, and jejunum fluids. The range of surface tensions for oral formulations were 36.6–64.7 dynes/cm. Nasal formulations had surface tensions below that of the normal mucosal lining fluid with a range of 30.3–44.9 dynes/cm. Ophthalmic OTC formulations had the largest range of surface tensions at the surface-to-air interface of 34.3–70.9 dynes/cm; however, all formulations indicated for treatment of dry eye had surface tensions higher than that of normal tears, while those for treatment of red eye had surface tensions below. Therefore, surface tension at the surface-to-air interface of liquid formulations is dependent on the route of administration, environment at site of introduction, and for ophthalmics, what the formulation is indicated for.

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Benzalkonium Chloride Accelerates the Formation of the Amyloid Fibrils of Corneal Dystrophy-associated Peptides

Cited by 14 publications

References 43 publications

Surface‐enhanced Raman scattering as a tool to study cationic surfactants exhibiting low critical micelle concentration

Surface‐enhanced Raman scattering as a tool to study cationic surfactants exhibiting low critical micelle concentration

Supersaturation-Limited and Unlimited Phase Spaces Compete to Produce Maximal Amyloid Fibrillation near the Critical Micelle Concentration of Sodium Dodecyl Sulfate

Surface tension examination of various liquid oral, nasal, and ophthalmic dosage forms

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