Benign Vascular Tumours of the Mediastinum; Presentation of Three Cases and Review of the Literature

Mineo, Tommaso Claudio; Biancari, Fausto; Cristino, Benedetto; D’Andrea, Vito

doi:10.1055/s-2007-1013811

Cited by 13 publications

(8 citation statements)

References 5 publications

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“…1 Soon thereafter, EH was reported in virtually every organ and anatomic site, ranging from the central nervous system to lymph nodes. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The liver is one of the better-documented primary sites of EH, likely due in part to the fact that hepatic transplantation is the treatment of choice, and identification of EH in the lung addressed the question of the nature of the so-called intravascular bronchioloalveolar tumor. 19 Each of the primary sites of EH carries its own site-specific differential diagnosis, which is certainly the case for primary EH of the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

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Primary Peritoneal Epithelioid Hemangioendothelioma

Posligua¹,

Anatelli²,

Dehner

et al. 2006

Int J Surg Pathol

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Epithelioid hemangioendothelioma is an uncommon malignant vascular tumor of intermediate grade that occurs in a variety of organs and soft tissues. Diagnosis of epithelioid hemangioendothelioma is often complicated by the rarity of the tumor, and because the tumor shares many morphologic features with other peritoneal neoplasms. This report presents 3 cases of epithelioid hemangioendotheliomas arising as primary tumors of the peritoneum and reviews 7 previously reported cases to establish the demographic, clinical, morphologic, immunohistochemical, and ultrastructural features of this neoplasm. These cases demonstrate that the light microscopic features are very similar to epithelioid hemangioendothelioma arising at more conventional sites, such as the liver, that immunohistochemical analysis provides a reliable approach for confirming or establishing the diagnosis, and that at least one endothelial marker (either CD31, CD34, or factor VIII) should be positive for a definitive diagnosis. This series identifies the characteristics of peritoneal epithelioid hemangioendothelioma that can be reliably used for diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…There is virtually no site which is immune to the occurrence of an EH. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The intermediate grade of this tumor does not belie its capacity for local recurrence and even distant metastasis. The overall mortality rate for EH is only about 13%, but is as high as 65% for tumors arising in the liver.…”

mentioning

confidence: 99%

Primary Peritoneal Epithelioid Hemangioendothelioma

Posligua¹,

Anatelli²,

Dehner

et al. 2006

Int J Surg Pathol

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“…Benign blood vessel tumours (hemangioma variants) have been reported as individual cases and have been summarized in several reviews [ 32 , 39 , 127 , 130 ]. Endothelial tumours of intermediate grade (hemangioendotheliomas) are characterized by local infiltrative growth and rare metastases.…”

Section: Vascular Tumoursmentioning

confidence: 99%

Mesenchymal tumours of the mediastinum—part II

et al. 2015

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“…They include hemangiopericytomas [6], hemangioendothelioma [7], soft-tissue angiosarcomas [8], pheochromocytomas [9], and some benign tumors [10]; for practical purposes, arteriovenous malformations [11] can also be included in this group. CD is another type of these hypervascular tumors.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Embolization of Hypervascular Castleman’s Disease of the Mediastinum

Robert

Sgourdos

Kritikos

et al. 2007

Cardiovasc Intervent Radiol

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We report the case of a 31-year-old woman with mediastinal CastlemanÕs disease of the hyaline vascular type. This large tumor was safely resected after arterial embolization. We describe the steps of this interventional procedure and discuss related necessary precautions.Key words: CastlemanÕs disease-Hypervasular tumors-Mediastinum-Arterial embolization CastlemanÕs disease (CD) is a rare form of lymph node hyperplasia, most commonly presenting as a solitary mediastinal mass. Computed tomography (CT) and angiographic features of CD are nonspecific [1] and a definite diagnosis is only based on histology findings. The surgical approach is usually curative when the disease is unicentric [2], but it is frequently associated with profuse bleeding. Only a few previous reports have suggested arterial embolization in the preoperative management of CD [3,4]. We report a case of localized CD presenting as a voluminous mass in the posterior mediastinum. Preoperative arterial embolization of this tumor minimized intraoperative bleeding. Case ReportA 31-year-old nonsmoking Asian woman with no medical history presented with a dry cough for 6 months without any other symptoms. An abnormal opacity in the posterior mediastinum was found on chest X-ray (Figs. 1A and 1B). CT confirmed the presence of a 12-cm homogeneous, welldelineated hypervascular right paravertebral mass of the posterior mediastinum (Fig. 1C). There was no evidence of pleural fluid or bone invasion. Laboratory investigations were within the normal range. Fine-needle aspiration or needle-core biopsy was not performed considering the risk of bleeding from this hypervascular mass and because of its location.A preoperative descending thoracic aortogram was obtained by means of a 5F pigtail catheter (Cordis, Roden, The Netherlands), in order to visualize the origin of the bronchial and extrabronchial arteries from the aorta. A selective bronchial arteriography by means of a 5F steam-modified Cobra catheter (Cordis, Roden, The Netherlands) supported the presence of a hypervascular mediastinal mass. The lesion was exclusively supplied by two arterial branches of a broncho-intercostal trunk originating from the descending thoracic aorta; it drained into large uphill inferior esophageal varices (Fig. 2). In a second step, embolization of these two feeding arteries was performed, in order to minimize intraoperative bleeding. The superior arterial branch, which supplied the superior and lateral portions of the mass, was selectively catheterized with a 2.5F microcatheter (Tracker 18; Boston Scientific, Cork, Ireland) and embolized by means of gelatin cross-linked tris-acryl microspheres 500-750 lm in diameter (Embospheres; Biosphere Medical, Roissy-Charles-de-Gaulle, France). Occlusion of the proximal segment was completed by three 3-0 silk threads (Silkam; Aesculap, Tuttlingen, Germany). The second arterial branch, which supplied the inferior and medial portions of the mass, was superselectively catheterized beyond the left bronchial artery and embolized in the sa...

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Benign Vascular Tumours of the Mediastinum; Presentation of Three Cases and Review of the Literature

Cited by 13 publications

References 5 publications

Primary Peritoneal Epithelioid Hemangioendothelioma

Primary Peritoneal Epithelioid Hemangioendothelioma

Mesenchymal tumours of the mediastinum—part II

Preoperative Embolization of Hypervascular Castleman’s Disease of the Mediastinum

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