Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin

Rosa, Ana Cláudia Garcia; Teixeira, Lucas Novaes; Passador-Santos, Fabrício; Furuse, Cristiane; Montalli, Victor Ângelo Martins; Araújo, Ney Soares de; Araújo, Vera Cavalcanti de

doi:10.1007/s00784-019-02863-7

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…Besides the importance to confirm the epithelial nature of GCONs, CKs expression can be important to understand the origin of these tumors, which remains unclear yet. CK7, CK14, and CK19 expression, as observed in some cases in our review, was previously reported in germinal dental tissues and other odontogenic tumors, reinforcing their odontogenic origin [4,60,61]. DGCTp was thought to arise from remnants of the dental lamina or alveolar mucosa surface epithelium [4,32], and the continuity of the basal layer with the tumor parenchyma was reported in 9 (17.3%) cases.…”

Section: Discussionsupporting

confidence: 81%

“…In vitro studies showed a key role of β-catenin in enhancing odontoblastic differentiation and dentin formation, presenting an explanation for the presence of dentinoid material in ghost cell odontogenic lesions [74]. Recently, some authors suggested an enameloid-like nature for this material due to its apparent secretion by peripheral ameloblast-like and mesenchymal cuboidal cells, expression of type 1 collagen (COL-1), and absence of amelogenin [61]. Plasmacytoid cells adjacent or interspersed with the dentinoid material were previously described by Stojanov and Woo [35] in a DGCT, which suggested a mesenchymal nature with secretory function of these cells due to positivity for vimentin and β-catenin and negativity for CKs [35].…”

Section: Expression Of β-Catenin In Neoplastic Cells Of Gcons Withmentioning

confidence: 99%

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Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Vieira

Montovani

Rozza-De-Menezes

et al. 2021

Head and Neck Pathol

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Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Case reports, series, and research studies with enough histopathological criteria for diagnosis and all genomic studies were included. Both DGCT and GCOC showed a male prevalence (p = 0.043), with mandibular and maxillary predilections, respectively (p = 0.008). Peripheral DGCT (DGCTp) affected most elderly people (p < 0.001), and central DGCT (DGCTc) and GCOC occurred mainly in younger individuals. Unilateral enlargement of maxilla or mandible was the most common clinical sign associated with a radiolucent or mixed image. Ameloblastomatous epithelium was often present in both neoplasms. Basaloid and large cells with vesicular nuclei were also frequently seen in GCOC. β-catenin expression and mutations (CTNNB1 gene) were found in DGCT and GCOC. Conservative surgery was mostly used for DGCTp, while radical resection was chosen for DGCTc and GCOC. High recurrence rates were found in DGCTc and GCOC. Metastasis occurred in 16.7% of GCOC cases and the 5-year survival rate was 72.6%. DGCT and GCOC share numerous clinicopathological features and demand a careful histopathological evaluation, considering the overlap features with other odontogenic tumors and the possibility of malignant transformation of DGCT. A strict regular post-operative follow-up is mandatory due to high recurrence rates and metastatic capacity in GCOC.

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Section: Discussionsupporting

confidence: 81%

Section: Expression Of β-Catenin In Neoplastic Cells Of Gcons Withmentioning

confidence: 99%

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Vieira

Montovani

Rozza-De-Menezes

et al. 2021

Head and Neck Pathol

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“…Our group suggested the term enameloid to describe the secreted material found in Gorlin cysts and substitute for terms like dentinoid or dysplastic dentin. 17 Outside the nodules and rosettes, we observed areas of eosinophilic material of different sizes interspersed by cuboidal small epithelial cells. These areas were devoid of columnar cells and far away from secretory cells.…”

Section: Discussionmentioning

confidence: 87%

Adenomatoid odontogenic tumor: Features of ameloblastic‐like epithelial cells differentiation, secretion, and the nature of tumor cells products

Passador-Santos

Oliveira

Teixeira

et al. 2023

J Oral Pathology Medicine

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BackgroundThis study aimed to investigate the differentiation of ameloblastic‐like cells and the nature of the secreted eosinophilic materials in adenomatoid odontogenic tumors.MethodsWe studied histological and immunohistochemical characteristics of 20 cases using: cytokeratins 14 and 19, amelogenin, collagen I, laminin, vimentin, and CD34.ResultsRosette cells differentiated into ameloblastic‐like cells positioned face‐to‐face, displaying collagen I‐positive material between them. Epithelial cells of the rosettes can differentiate into ameloblastic‐like cells. This phenomenon probably occurs due to an induction phenomenon between these cells. The secretion of collagen I is probably a brief event. Amelogenin‐positive areas were interspersed by epithelial cells in the lace‐like areas, outside the rosettes and distant from the ameloblastic‐like cells.ConclusionsThere are at least two types of eosinophilic material in different areas within the tumor, one in the rosette and solid areas and another in lace‐like areas. The secreted eosinophilic material in the rosettes and solid areas is probably a product of well‐differentiated ameloblastic‐like cells. It is positive for collagen I and negative for amelogenin, whereas some eosinophilic materials in the lace‐like areas are positive for amelogenin. We hypothesize that the latter eosinophilic material could be a product of odontogenic cuboidal epithelial or intermediate stratum‐like epithelial cells.

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“…Nowadays, all these oral calcifying cystic lesions could be considered as a family of pathologic entities which includes heterogeneous groups of oral cystic lesions with benign, locally aggressive or malignant behavior which can be defined benign odontogenic ghost cell lesions (BOGCL) [10] [11] [12]. The true COC is a rare entity in the oral cavity and represents about less than 1% of all odontogenic lesions.…”

Section: Introductionmentioning

confidence: 99%

“…because it could be a transitory and short phase and the secreted tissue could change, losing the characteristics of the enameloid-like substance[12] [14].GCs have been also compared with those found in the calcifying epithelioma of Malherbe in the skin, craniopharyngioma, pilomatrixoma[9] [15]. The GCs are found in groups, particularly in the thicker areas of the epithelial lining[4].The spinous cells in such situations may be widely separated by intercellular edema and the epithelium around the ghost cells is often convoluted[9].As histology tells us, the morphology of odontogenic lesions recalls the stages of embryonic development of the teeth [9] [12] while the alterations of the molecular mechanisms of odontogenesis have been associated with the formation of various odontogenic pathological entities [13] [14].…”

mentioning

confidence: 99%

Calcifying Odontogenic Cyst of the Oral Cavity: A Clinical Case and Current Updates on the Ethiopathogenesis

Menditti¹,

D'Amato²,

Laino³

et al. 2020

OJST

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Background: The calcifying odontogenic cyst (COC) is a rare pathological entity. It falls into a group of lesions with calcifications that present benign and sometime malignant tumor variants. Case Presentation: In the present study, we report on a case of intraosseous/intrasinusal COC with impacted maxillary canine and dentinoid structures odontoma-like. The clinical, radiographical, histopathological, and molecular characteristics of this pathological entity are discussed in relation also to the problems of differential diagnosis, treatment, and prognosis. Conclusion: The true COC is a rare entity in the oral cavity and represents about less than 1% of all odontogenic lesions. Careful clinical, instrumental and histological analysis must be performed for odontogenic cysts in order to accomplish the correct surgical act and to avoid recurrence.

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Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin

Cited by 6 publications

References 27 publications

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Adenomatoid odontogenic tumor: Features of ameloblastic‐like epithelial cells differentiation, secretion, and the nature of tumor cells products

Calcifying Odontogenic Cyst of the Oral Cavity: A Clinical Case and Current Updates on the Ethiopathogenesis

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