Benign familial chronic pemphigus treated with dapsone

Sequential treatments of Hailey‐Hailey disease with photodynamic therapy, botulinum toxin type A and dapsone: A case report

“…Guarino et al report a failed experience in the three patients treated with a similar treatment regimen 23 ; conversely, there are two recent papers which report a complete response achieved 24 and a complete response with no recurrences in three other patients. 25 Dapsone is an antimicrobial agent rarely used in HHD and there is only one paper in literature reporting clinical remission of three patients treated with an oral regimen of dapsone with a starting dose of 100-200 mg per day, followed by a maintenance dose of 50 mg. 26 Thus it could be considered as a useful maintenance drug in this disease.…”

“…Dapsone is an antimicrobial agent rarely used in HHD and there is only one paper in literature reporting clinical remission of three patients treated with an oral regimen of dapsone with a starting dose of 100–200 mg per day, followed by a maintenance dose of 50 mg 26 . Thus it could be considered as a useful maintenance drug in this disease.…”

Darier and Hailey‐Hailey disease: update 2021

“…There are also individual case reports on successful treatment with: –Doxycycline (100 mg per day) [94] –Methotrexate (7.5–15 mg per week) [95–97] –Dapsone (initially 50–200 mg per day, with subsequent reduction to 50 mg) [98] –Etanercept (one positive case report; 75 mg per week) [99] –Azathioprine [100] –Ciclosporin (2.5 mg/kg BW per day) [101, 102] –Thalidomide (initially 100 mg 3 x per day, maintenance dose 50 mg per day) [103] –Terbinafine (250 mg per day) [104] …”

Morbus Darier und Morbus Hailey‐Hailey: Stand 2021

“…-Doxycyclin (100 mg täglich) [94] -Methotrexat (7,5-15 mg wöchentlich) [95][96][97] -Dapson (initial 50-200 mg täglich, im Verlauf Reduktion auf 50 mg) [98] -Etanercept (1 positiver Fallbericht; 75 mg wöchentlich) [99] -Azathioprin [100] -Ciclosporin (2,5 mg/kg KG täglich) [101,102] -Thalidomid (initial 100 mg 3 x täglich, Erhaltungsdosis 50 mg täglich) [103] -Terbinafin (250 mg täglich) [104] Da bekannt ist, dass die defekte Calciumpumpe Magnesium-abhängig ist, wurden einige Patienten erfolgreich mit Magnesium 300 mg täglich behandelt [105,106].…”

“…Berichte über Erfolge in Einzelfällen liegen außerdem für folgende Medikamente vor: –Doxycyclin (100 mg täglich) [94] –Methotrexat (7,5–15 mg wöchentlich) [95–97] –Dapson (initial 50–200 mg täglich, im Verlauf Reduktion auf 50 mg) [98] –Etanercept (1 positiver Fallbericht; 75 mg wöchentlich) [99] –Azathioprin [100] –Ciclosporin (2,5 mg/kg KG täglich) [101, 102] –Thalidomid (initial 100 mg 3 x täglich, Erhaltungsdosis 50 mg täglich) [103] –Terbinafin (250 mg täglich) [104] …”