Benign Familial Chronic Pemphigus Treated With Dapsone

Bullous Pemphigoid Controlled by Dapsone

“…Dapsone was chosen since it has been used effec tively to control immunological disorders such as classical DH, pemphigoid [C horzelski and J ablonska, 1975; van der M eer, 1969; P ia m ph o n g sa n t ei al. 1976; Stone, 1974], pemphigus [Piam ph o n g sa n t, 1976] and vasculitis [Cream el al., 1971], It has been also effective in other vesiculo-bullous erup tions such as subcorneal pustular dermatosis (Sneddon-Wilkinson disease), generalized pustular psoriasis [M a c M illan and C h a m pio n , 1973], and benign familial chronic pemphigus [Sire and Johnson, 1971], Similar cases have also been successfully controlled by dapsone at our Institute. The mechanism of action in these diseases is not known, but it could act by inhibiting lysosomal enzymes [Barranco, 1974;M ier and H u r k , 1975].…”

Dapsone in the Treatment of Pemphigus Vulgaris

“…Since then, the therapeutic response of a bullous dermatosis to dapsone has often been considered as a diagnostic criterion in these conditions. However, dapsone has also been shown to be effective in a number of other processes such as: allergic vasculitis [8,9]; erythema elevatum diutinum [10,11]; generalized pustular psoriasis [12], benign familial pemphigus [13] and in bullous pemphigoid as well [14]. The mechanism of action of sulfones in these disorders is as yet unknown.…”

Morbus Darier und Morbus Hailey‐Hailey: Stand 2021

“…-Doxycyclin (100 mg täglich) [94] -Methotrexat (7,5-15 mg wöchentlich) [95][96][97] -Dapson (initial 50-200 mg täglich, im Verlauf Reduktion auf 50 mg) [98] -Etanercept (1 positiver Fallbericht; 75 mg wöchentlich) [99] -Azathioprin [100] -Ciclosporin (2,5 mg/kg KG täglich) [101,102] -Thalidomid (initial 100 mg 3 x täglich, Erhaltungsdosis 50 mg täglich) [103] -Terbinafin (250 mg täglich) [104] Da bekannt ist, dass die defekte Calciumpumpe Magnesium-abhängig ist, wurden einige Patienten erfolgreich mit Magnesium 300 mg täglich behandelt [105,106].…”