Benefits of linked color imaging for recognition of early differentiated-type gastric cancer: in comparison with indigo carmine contrast method and blue laser imaging

Yasuda, Takeshi; Yagi, Nobuaki; Omatsu, Tatsushi; Hayashi, Shigeo; Nakahata, Yuki; Yasuda, Yuriko; Obora, Akihiro; Kojima, Takao; Naito, Yuji; Itoh, Yoshito

doi:10.1007/s00464-020-07706-1

Cited by 15 publications

(10 citation statements)

References 22 publications

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Section: Discussionmentioning

confidence: 99%

“…It is unknown how many EGCs that are poorly visible using WLI can be recognized with LCI, despite reports describing improved visibility for EGCs compared with other modalities. 6,18 In a recent randomized clinical trial of the detection of neoplastic lesions in the upper gastrointestinal tract, the miss rate of neoplasms was 39% with WLI and 7% with LCI. 11 In the present study, the improved rate of visibility (46.4%) of EGCs is much higher than the rate of deteriorated visibility (4.9%) when the endoscopic modality changed from WLI to LCI.…”

Section: Discussionmentioning

confidence: 99%

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Usefulness of linked color imaging for the detection of obscure early gastric cancer: Multivariate analysis of 508 lesions

Khurelbaatar

Mıura

Osawa

et al. 2022

Digestive Endoscopy

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Objectives Early gastric cancers (EGCs) of the elevated type or with submucosal invasion are easily found by routine endoscopy. However, most early cancers are challenging to detect because of subtle morphological or color differences from surrounding atrophic mucosa and intestinal metaplasia. Linked color imaging (LCI) enhances mucosal color difference, making it easier to detect EGCs. The aim of this study is to clarify the advantages and possible disadvantages of LCI for screening for obscure EGC. Methods A total of 665 malignant gastric lesions resected using endoscopic submucosal dissection between January 2015 and April 2018 were retrospectively reviewed. Obviously detectable lesions were not included in the main analysis when determining the target lesion. White light imaging (WLI)/LCI images of 508 endoscopically obscure malignant lesions were included in the final analysis and evaluated by three non‐expert and three expert endoscopists using visibility scores for detection and extent. Results The detection visibility scores using LCI were significantly higher than those using WLI regardless of lesion characteristics including location, size, histological type, depth of invasion, and Helicobacter pylori status. The detection score improved in 46.4% cases and deteriorated in 4.9% when the modality changed from WLI to LCI. A mixed‐effects multivariate logistic regression analysis showed that use of LCI (odds ratio [OR] 2.57), elevated type (OR 1.92), invasion to submucosa (OR 2.18) were significantly associated with improved visibility of EGC. Conclusions Linked color imaging significantly improves visibility of EGC regardless of differences in lesion morphology, histology, location, depth of invasion, and H. pylori status compared to conventional WLI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Usefulness of linked color imaging for the detection of obscure early gastric cancer: Multivariate analysis of 508 lesions

Khurelbaatar

Mıura

Osawa

et al. 2022

Digestive Endoscopy

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“…In addition, other innovative endoscopic methods were proposed for increasing the accuracy of biopsy collection [ 46 ]. Multiple recent studies underlined the utility of blue laser imaging in diagnosing gastric cancer regardless of the stage and even gastric metaplasia [ 47 , 48 , 49 , 50 , 51 ] ( Table 1 ).…”

Section: Who Should Be Tested Why and How To Choose The Testing Method?mentioning

confidence: 99%

Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection

2022

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Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, is usually acquired during childhood and is related to gastric carcinogenesis during adulthood. Therefore, its early proper diagnosis and subsequent successful eradication represent the cornerstones of gastric cancer prevention. The aim of this narrative review was to assess traditional and modern diagnostic methods in terms of H. pylori diagnosis. Several invasive and non-invasive methods were described, each with its pros and cons. The invasive diagnostic methods comprise endoscopy with biopsy, rapid urease tests, histopathological exams, cultures and biopsy-based molecular tests. Among these, probably the most available, accurate and cost-effective test remains histology, albeit molecular tests definitely remain the most accurate despite their high costs. The non-invasive tests consist of urea breath tests, serology, stool antigens and non-invasive molecular tests. Urea breath tests and stool antigens are the most useful in clinical practice both for the diagnosis of H. pylori infection and for monitoring the eradication of this infection after therapy. The challenges related to accurate diagnosis lead to a choice that must be based on H. pylori virulence, environmental factors and host peculiarities.

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“…The reported studies show that a combination of random and targeted therapies increases the sensitivity of gastroscopy in CDH1 mutation gene carriers and that endoscopic surveillance is an option especially with high resolution and high-definition endoscopes with advanced endoscopic imaging [ 80 ]. As CDH1 mutation carriers harbor an approximately 70% lifetime risk of gastric cancer in men and 56% in women [ 4 ], the critical question remains as to whether endoscopic surveillance only unnecessarily delays a gastrectomy.…”

Section: Implications Of Cdh1 Gene Alterations In ...mentioning

confidence: 99%

Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches

Cosma

Schlosser

Tews

et al. 2022

IJMS

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Hereditary diffuse gastric cancer is an autosomal dominant syndrome characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is caused by inactivating mutations in the tumor suppressor gene CDH1. Genetic testing technologies have become more efficient over the years, also enabling the discovery of other susceptibility genes for gastric cancer, such as CTNNA1 among the most important genes. The diagnosis of pathogenic variant carriers with an increased risk of developing gastric cancer is a selection process involving a multidisciplinary team. To achieve optimal long-term results, it requires shared decision-making in risk management. In this review, we present a synopsis of the molecular changes and current therapeutic approaches in HDGC based on the current literature.

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Benefits of linked color imaging for recognition of early differentiated-type gastric cancer: in comparison with indigo carmine contrast method and blue laser imaging

Cited by 15 publications

References 22 publications

Usefulness of linked color imaging for the detection of obscure early gastric cancer: Multivariate analysis of 508 lesions

Usefulness of linked color imaging for the detection of obscure early gastric cancer: Multivariate analysis of 508 lesions

Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection

Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches

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