Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis

Toumi, Ryma; Abdelouhab, Katia; Rafa, Hayet; Soufli, Imene; Raissi-Kerboua, Djamila; Djeraba, Zineb; Touil-Boukoffa, Chafia

doi:10.3109/08923973.2013.790413

Cited by 59 publications

(47 citation statements)

References 39 publications

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“…The DSS+Prb group received 3% (w/v) of DSS for 5 days and 10 9 CFU/ml of probiotic for 7 days starting from day 3 to the end of the experimental period. The Prb group received 10 9 CFU/ml of probiotic for 7 days starting from day 3. The mice were fed with 200 ul, of daily-prepared suspension of the probiotic formula in skimmed milk by oral gavage.…”

Section: Methodsmentioning

confidence: 99%

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Probiotic Bacteria Lactobacillus and Bifidobacterium Attenuate Inflammation in Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

Toumi

Soufli

Rafa

et al. 2014

Int J Immunopathol Pharmacol

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It is widely accepted that inflammatory Bowel disease (IBD) arises from a dysregulated mucosal immune response to the enteric microbiota in the gut of a genetically susceptible individual. No definitive therapies are available for this inflammatory disorder. Therefore it became imperative to develop new strategies for treating this disease. Probiotics have emerged as a potential new therapeutic strategy for IBD, however their exact mechanisms of action is still poorly defined. In this study, we address the potential effect of a probiotic cocktail (Ultrabletique") composed of four live bacterial strains (L. acidophilus, L. plantarum, B. lactis and B.breve) to promote recovery from acute colitis. Probiotic was given to mice by oral gavage after the onset of colitis and the establishment of dextran sulfate sodium (DSS)-induced intestinal injury. Clinical parameters were monitored daily, histological scores of colitis and the production of nitric oxide (NO) and interferon-y (IFN-y) were determined. In addition, TLR4, NF-KB and iNOS colonic expression were examined. Probiotic treatment ameliorated clinical symptoms and histological scores. NO and IFN-y production in plasma were decreased by probiotic. These results were associated with reduced

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Section: Methodsmentioning

confidence: 99%

“…They are described as "live microorganisms which, when ingested in sufficient numbers, convey health benefits to the host" (14). Current data, obtained mainly from animal models of colitis studies, suggest that probiotics such as Bifidobacterium and Lactobacillus improve barrier function and preserve the intestinal epithelial barrier (10,15).…”

mentioning

confidence: 99%

Probiotic Bacteria Lactobacillus and Bifidobacterium Attenuate Inflammation in Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

Toumi

Soufli

Rafa

et al. 2014

Int J Immunopathol Pharmacol

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“…LAB such as L. rhamnosus and probiotic mixture composed of L. acidophilus, B. lactis, L. plantarum, and B. breve have shown protection against DSS-induced colitis [40, 41]. IL-10 was not elevated in our experiments, but several studies have reported that Lactobacillus , Bifidobacterium and Streptococcus species induce the production of anti-inflammatory IL-10, although with different effectiveness [42–44].…”

Section: Discussionmentioning

confidence: 62%

Protective Effect ofLaminaria japonicawith Probiotics on Murine Colitis

Bae

et al. 2014

Mediators of Inflammation

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Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions. Laminaria japonica (LJ) is an edible seaweed used to regulate digestive symptoms. Probiotics have been reported to improve digestive problems and their simultaneous administration with seaweeds has been shown to produce synergistic therapeutic effects. Here, we investigated the effect of LJ combination with probiotics on dextran sodium sulfate-induced colitis model in mice. Aqueous LJ extracts (LJE) at doses from 100 to 300 mg/kg and probiotics at a dose of 300 mg/kg were orally administered for 7 days. Body weight, colon length, histological score, macroscopic damage, and the levels of cytokines IFN-γ, IL-1β, IL-6, IL-10, IL-12 (P40), IL-12 (P70), IL-17, and TNF-α were assessed. LJE alone caused a significant improvement of colitis signs such as colon length, histological score, and IL-1β and IL-6 production. LJE and probiotics demonstrated a synergistic effect by the histological score and levels of IL-1β, IL-6, and IL-12 (P40) but not IFN-γ, IL-10, and IL-12 (P70). In conclusion, LJE was effective in inducing protection against colitis in mice and acted synergistically with probiotics.

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“…Imbalances in Al, Fe, Cu and Zn levels caused by Al overload can lead to obvious oxidative stress in liver, which further results in damage to hepatic cells and liver dysfunction [36]. Probiotic can alleviate Al toxicity via many mechanisms such as reducing oxidative stress, inhibiting NO synthase-2 expression and so on [37, 38]. When NO is produced in excess, it causes deleterious effect indirectly through the creation of reactive nitric oxygen species (RNOS), responsible for the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

Tian

Zhai

et al. 2017

PLoS ONE

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Our previous study found that Lactobacillus plantarum CCFM639 had the ability to alleviate acute aluminum (Al) toxicity when the strain was introduced simultaneously with Al exposure. This research was designed to elucidate the therapeutic effects of living and dead L. plantarum CCFM639 against chronic Al toxicity and to gain insight into the protection modes of this strain. Animals were assigned into control, Al only, Al + living CCFM639, and Al + dead CCFM639 groups. The Al exposure model was established by drinking water for the first 4 weeks. The strain was given after Al exposure by oral gavage at 109 colony-forming units once per day for 12 weeks. The results show that the Al binding ability of dead CCFM639 was similar to that of living CCFM639 in vitro. The ingestion of living or dead CCFM639 has similar effects on levels of Al and trace element in tissues, but living strains led to more significant amelioration of oxidative stress and improvement of memory deficits in Al-exposed mice. In conclusion, in addition to intestinal Al sequestration, CCFM639 treatment offers direct protection against chronic Al toxicity by alleviation of oxidative stress. Therefore, L. plantarum CCFM639 has a potential as dietary supplement ingredient that provides protection against Al-induced injury.

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Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis

Cited by 59 publications

References 39 publications

Probiotic Bacteria Lactobacillus and Bifidobacterium Attenuate Inflammation in Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

Probiotic Bacteria Lactobacillus and Bifidobacterium Attenuate Inflammation in Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

Protective Effect ofLaminaria japonicawith Probiotics on Murine Colitis

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

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