volume 4, issue 11, P755-767 2012
DOI: 10.18632/aging.100504
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Miklos Jaszberenyi, Ferenc G. Rick, Luca Szalontay, Norman L. Block, Marta Zarandi, Ren-Zhi Cai, Andrew V. Schally

Abstract: Alzheimer's disease is the most frequent debilitating disorder of the central nervous system. Neuroendocrine mechanisms appear to play an important role in this insidiously developing disease. In the present study, the effects of a recently developed growth hormone-releasing hormone (GHRH) antagonist (MIA-690) were evaluated in vivo observing the behavior of genetically modified “Alzheimer's” 5XFAD mice in a Morris water maze (MWM). The effects of the antagonist were also evaluated in vitro using HCN2 human co…

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