Beneficial Effects of Calcium Channel Blocker “Nifedipine” on Abnormalities of Platelets and Lipid Metabolism in Patients with Type II Diabetes Mellitus

Emara, Elsayed A.; Abdel-Sater, Khaled A.

doi:10.4172/2155-6156.1000131

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…In a study performed to investigate the beneficial effects of nifedipine on abnormalities of platelets and lipid metabolism in patients with type II diabetes mellitus, it was found nifedipine produced significant reduction of lipid profiles except for HDL which showed significant increase 15 . This result agrees with our findings which demonstrated that nifedipine produced highly significant reduction in LDL-cholesterol blood level in rats.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine

Hassan¹,

Mudawi²,

Sulaiman³

2016

AJPRHC

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Metformin is now being recognized as the standard therapy in T2D patients who are overweight. Metformin has many drug-disease interactions that can increase the risk of metformin-associated lactic acidosis. Therefore this study was conducted to evaluate any possible pharmacodynamic interactions between metformin and drugs used to treat chronic diseases e.g. Hypertension. The rats were fasted overnight before inducing diabetes with streptozotocin. The rats were given an intraperitoneal injection of streptozotocin (50 mg kg−1) freshly prepared in 0.1M sodium citrate buffer. The diabetic state was confirmed 72 h after streptozotocin injection. Diabetic rats were grouped into seven groups each group of five rats and distributed among the normal control group diabetic control group and the treatment groups. The treatment continued for 10 days. Blood samples were taken before treatment and after 10 days and analyzed for serum glucose, cholesterol, HDL, LDL, and triglycerides. In the diabetic control group which was given STZ alone the blood glucose level decreased significantly (p < 0.05) after 10 days but still above the hyperglycemic level (200mg/dl). The same was observed in the group treated with metformin. The group treated with nifedipine and aspirin showed significant reduction (p < 0.01) in the glucose level below the hyperglycemic level (200mg/dl). While the groups treated with (Metformin + Nifedipine) and (Metformin +Aspirin) showed highly significant reduction (P<0.001) in blood glucose level. These results conclude that the combination of (metformin +Nifedipine) and the combination of (Metformin + Aspirin) have highly significant hypoglycemic effect. It also showed that Nifedipine has promising role in reducing blood glucose level, lipid profile especially LDL-cholesterol, and body weight.

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Section: Discussionmentioning

confidence: 99%

Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine

Hassan¹,

Mudawi²,

Sulaiman³

2016

AJPRHC

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“…In severe tuberculosis, endocrine function of Pancreas has also been found to be adversely affected. In patients with concomitant diabetes and tuberculosis, a higher incidence of chronic calcific pancreatitis occurs, leading to an absolute or relative insulin deficiency state [80]. Dysregulation of energy homeostasis in the TB disease may cause by a family of fattyacid-transporter proteins in the tubercle bacillus.…”

Section: Causes Of Glucose Intolerance In Tuberculosismentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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“…Hyperglycemia-derived oxygen free radicals are also considered mediators of diabetic complications [37]. Hyperglycemia changes platelet function [38] by impairing calcium homeostasis and thereby alters aspects of platelet activation and aggregation, including platelet conformation and release of mediators. Diabetes is much more complicated than hyperglycemia and is associated with several risk factors.…”

Section: Alterations In Glucose Levelsmentioning

confidence: 99%

Late Stage Complications of Diabetes and Insulin Resistance

Soumya¹,

Srilatha²

2011

J Diabetes Metab

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Diabetes mellitus is considered one of the main threats to human health in the 21st century. Diabetes is a metabolic disorder or a chronic condition where the sugar levels in blood are high. Diabetes is associated with long-term complications that affect almost every part of the body and often leads to blindness, heart and blood vessel disease, stroke, kidney failure, amputations, and nerve damage. Also it is associated with significantly accelerated rates of several debilitating microvascular complications such as nephropathy, retinopathy, and neuropathy, and macrovascular complications such as atherosclerosis and stroke. In the present article it has been discussed about the resistance of insulin and its consequences in diabetic patients. Insulin resistance results in various disorders. Metabolic syndrome is predicted to become a major public health problem in many developed, as well as developing countries. J ou rna l o f D ia be tes & M e ta bolism

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Beneficial Effects of Calcium Channel Blocker “Nifedipine” on Abnormalities of Platelets and Lipid Metabolism in Patients with Type II Diabetes Mellitus

Cited by 11 publications

References 37 publications

Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine

Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine

Role of Diabetes in prevalence of Tuberculosis

Late Stage Complications of Diabetes and Insulin Resistance

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