Beneficial Effect of Measles on Nephrosis

Comprehensive Review of Steroid-Sensitive Nephrotic Syndrome Genetic Risk Loci and Transcriptional Regulation as a Possible Mechanistic Link to Disease Risk

“…Studies using larger populations are therefore needed in order to identify more robust associations. In addition, the fact that (47,48) and the association of nephrotic syndrome with T cell lymphomas (49). Finally, as described above, several genetic variants in the human leukocyte antigen (HLA) region have been shown to associate with SSNS in multiple studies (18,19,21,22), although the mechanisms underlying these associations have not yet been elucidated.…”

Viral-associated glomerulopathies in children

“…His remission lasted only until resolution of flu symptoms, at which time the NS relapsed. Other investigations have been able to associate measles infection with remission of idiopathic NS in children [ 45 , 46 ], and inoculation was tested in two children as a form of therapy. In total, 13 of 21 children reported in the literature had remissions within 1 week of developing exanthema.…”

The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome

“…Furthermore, there is good evidence to suggest that the immune system, and specifically T lymphocyte dysfunction, may be involved in other non-genetic forms of nephrotic syndrome. This is supported by the knowledge that nephrotic syndrome responds to corticosteroids and other immunosuppressive medications [reviewed by (8)], by cases of nephrotic syndrome resolving following measles infection (9), and by the association between T cell lymphoma and the diagnosis of nephrotic syndrome (10). Finally, it is theorized that a circulating glomerular permeability factor is responsible for some forms of nephrotic syndrome, though a specific putative factor has yet to be identified.…”