Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects

Carvalho, Vivian Maria Souza de; Covre, Joyce Luciana; Correia-Silva, Rebeca D.; Lice, Izabella; Corrêa, Maria José Pinheiro; Leopoldino, Andréia Machado; Gil, Cristiane Damas

doi:10.1016/j.jphotobiol.2021.112247

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…As the Polypodium leucotomos extract (Biofarma) is known for photoprotective effects in vitro and in vivo, it was used as a positive control. The 1% P. leucotomos and 1% B. perennis extracts showed similar effects on the cells [26].…”

Section: Effects On Skin and Wound Healingmentioning

confidence: 71%

(Bio)active Compounds in Daisy Flower (Bellis perennis)

Albien,

Stark

2023

Molecules

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The common daisy (Bellis perennis) belongs to the family Asteraceae and, in recent years, some new research has been published on the bioactive compounds and biological activities of its extracts. In 2014, the knowledge was partially summarized, but several new studies have been published in the last nine years. In addition, the substances were tabularly consolidated to give a comprehensive overview of over 310 individual components, compound classes, and bioactivities, as well as their accurate plant organ origin. The latest results have shown that the plant has antioxidative, antimicrobial, anticancerogenic, wound healing, antidepressive, anxiolytic, nephroprotective, and insulin mimetic effects, as well as an effect on lipid metabolism. Some studies in the field of homeopathy were also listed. Ideally, a biological effect and one or several compound(s) can be correlated. However, the compounds of the extracts used have often been qualified and quantified, but it remains unclear which of these substances have an activity. The works often stick at the level of the crude extract or a fraction, but not at a single purified and tested compound and, consequently, they are hampered by a missing comprehensive bioactivity workflow. This review provides a critical overview and gaps and offers a basis for further research in this area.

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Section: Effects On Skin and Wound Healingmentioning

confidence: 71%

(Bio)active Compounds in Daisy Flower (Bellis perennis)

Albien,

Stark

2023

Molecules

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“…También se ha reportado su actividad antiinflamatoria, antipirética, antiespasmódica, astringente, depurativa, diurética, expectorante, mucolítica, disolvente, tónica y vulneraria (Duke et al, 2002). Se han identificado en sus flores saponinas triterpénicas de tipo oleanano, flavonoides y poliacetilenos en extractos (Avato et al, 1997;Costa Marques et al, 2013;Morikawa et al, 2015) y se ha demostrado su actividad antihiperlipidémica, antitumoral, reductora de la glucosa en sangre, fotoprotectora e inmunomoduladora en los queratinocitos de la piel, reductora de la pérdida de sangre posparto, promotora de la síntesis de colágeno en fibroblastos dérmicos, antioxidante, inhibidora de la acetilcolinesterasa y antimicrobiana (Avato et al, 1997;Oberbauma et al, 2005;Morikawa et al, 2010;Costa Marques et al, 2013; Pehlivan Karakas et al, 2014;Morikawa et al, 2015;Haselgrübler et al, 2018;Souza de Carvalho et al, 2021). Sturms et al, 1905: t. 9;Cabrera, 1971: 19, fig.…”

Section: Usos Y Propiedadesunclassified

Primer registro de la especie exótica Bellis perennis (Asteraceae, Astereae) en la Provincia de Buenos Aires, centro de Argentina

Vercelli

Scaramuzzino

Goyenetche

2022

LIL

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Bellis perennis (Asteraceae, Astereae), especie de uso ornamental y maleza de cultivos agrícolas, se encuentra naturalizada en diferentes partes del mundo. Hasta el momento, en Argentina solo había sido registrada en el extremo sur, en las provincias patagónicas de Chubut y Tierra del Fuego e Islas del Atlántico sur, incluyendo las islas Malvinas. Se comunica la presencia de esta especie exótica en la Provincia de Buenos Aires, en los partidos de Azul y Olavarría, constituyendo el primer registro para el centro de Argentina en su área pampeana. Se describe, se ilustra con fotografías y se presentan nuevas observaciones respecto a su distribución y hábitat.

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“…Ultraviolet rays cause skin damage by inducing oxidative stress (OS) and prime photo aging and cancer in skin cells [ 1 , 2 , 3 ]. Ultraviolet A (UVA) constitutes 90% of ultraviolet light and can penetrate keratinocytes and eventually cause cell apoptosis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

Hui

Yang

Fang

et al. 2022

CIMB

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Excessive reactive oxygen species (ROS), a highly reactive substance that contains oxygen, induced by ultraviolet A (UVA) cause oxidative damage to skin. We confirmed that hemin can catalyze the reaction of tyrosine (Tyr) and hydrogen peroxide (H2O2). Catalysis was found to effectively reduce or eliminate oxidative damage to cells induced by H2O2 or UVA. The scavenging effects of hemin for other free-radical ROS were also evaluated through pyrogallol autoxidation, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·)-scavenging assays, and phenanthroline–Fe2+ assays. The results show that a mixture of hemin and tyrosine exhibits strong scavenging activities for H2O2, superoxide anion (O2−·), DPPH·, and the hydroxyl radical (·OH). Furthermore, the inhibition of oxidative damage to human skin keratinocyte (HaCaT) cells induced by H2O2 or UVA was evaluated. The results show that catalysis can significantly reduce the ratio of cell apoptosis and death and inhibit the release of lactate dehydrogenase (LDH), as well as accumulation of malondialdehyde (MDA). Furthermore, the resistance to apoptosis was found to be enhanced. These results show that the mixture of hemin and tyrosine has a significantly protective effect against oxidative damage to HaCaT cells caused by UVA, suggesting it as a protective agent for combating UVA damage.

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Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects

Cited by 8 publications

References 39 publications

(Bio)active Compounds in Daisy Flower (Bellis perennis)

(Bio)active Compounds in Daisy Flower (Bellis perennis)

Primer registro de la especie exótica Bellis perennis (Asteraceae, Astereae) en la Provincia de Buenos Aires, centro de Argentina

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

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