Behçetʼs Disease. Report of 41 Cases and a Review of the Literature

Chajek, T.; Fainaru, M

doi:10.1097/00005792-197505000-00001

Cited by 549 publications

(187 citation statements)

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“…1,2 Ocular involvement in Behçet's disease is characterized by recurrent episodes of intraocular inflammation or uveitis, most commonly presenting as retinal vasculitis. 3 In addition, some reports suggest that choroidal abnormalities can be observed by indocyanine green angiography (ICGA) and fluorescein angiography (FA). [4][5][6] Although recurrent ocular attacks may lead to irreversible alterations of the sensory retina, which are significant causes of poor visual prognosis in affected patients, 7 to the best of our knowledge, details of the structural changes in affected retinas have not been documented.…”

Section: Introductionmentioning

confidence: 99%

Structural changes of fovea during remission of Behçet's disease as imaged by spectral domain optical coherence tomography

Unoki

Nishijima

Kita

et al. 2009

Eye

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Section: Introductionmentioning

confidence: 99%

Structural changes of fovea during remission of Behçet's disease as imaged by spectral domain optical coherence tomography

Unoki

Nishijima

Kita

et al. 2009

Eye

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“…1 It has been shown that the common histological lesion of all clinical manifestations appears to be vasculitis. 4,5 Many studies concerning the vascular involvement and the thrombotic Also, the finding of decreased plasminogen fibrinolytic activity in patients with active BD presents a possible disturbance in the blood coagulation mechanism in BD patients. 6 Notably, the issue of CV involvement in BD, which was thought to be a relatively rare manifestation of the disease, has attracted much attention of cardiologists over the past few decades, owning to the widespread use of highly informative diagnostic techniques, such as echocardiography.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of studies have shown a linkage between the disease and HLA-B51 and HLA-B27 antigens. [1][2][3][4] Vasculitis is the underlying pathological process, in contrast to the classic triad of recurrent urogenital ulcerations, with uveitis. 5,6 Vascular involvement in BD includes venous thrombosis, arterial occlusion, pulmonary artery, and aortic aneurysm formation.…”

mentioning

confidence: 99%

Cardiovascular Involvement in Behçet Disease: Clinical Implications

et al. 2015

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Beh?et disease (BD) is a multisystem disorder, with vasculitis as its underlying pathological process, in contrast to the classic triad of recurrent oral and genital ulcerations, with uveitis. Vascular involvement in BD includes venous thrombosis, arterial occlusion, and pulmonary artery and aortic aneurysm formation. Cardiac involvement is rare and often obscure. It includes intracardiac thrombi formation, and is associated with a poor prognosis. Our objectives are to describe two cases with BD, complicated with vascular and cardiac involvement, and to raise awareness of these rare complications, the needed routine surveillance, and thus to prevent inappropriate interventions, serious outcomes, and mortality. We present two male patients from the Mediterranean Basin with BD. The first was diagnosed early as a BD patient. The second was diagnosed at the time of cardiovascular (CV) involvement. We recommend that patients who are diagnosed, or even suspected of suffering from BD, especially in endemic areas along the Silk Route pathway, should be followed up routinely for CV involvement, even if rare, obscure, or with a bizarre presentation.

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“…The etiological cause of BD is not yet clarified, however, clinically, thrombophlebitis occurs in 30% of BD patients and vascular damages such as erythema nodosum and ulcers are often shown [15]. Also, histopathologically, complement mediated vasculitis or lymphocytic vasculitis is often observed [3,16,17].…”

Section: Discussionmentioning

confidence: 99%