Behcet's disease, painful genital ulcerations and steroid pulse therapy

Aldeen, Taha

doi:10.1136/bcr.07.2008.0353

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Colchicine or apremilast is recommended to prevent recurrent oral and genital ulcers (10). Other therapeutic options might also be prescribed, such as thalidomide, interferon alfa, cyclosporine, tumor necrosis factor-alpha inhibitors, and azathioprine, depending on the presence of other organ involvement (6).…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Genital Ulcer: An Unusual Presentation of Behçet’s Disease: A Case Report

Almheirat,

Kaddar,

Elyamani

et al. 2023

J Skin Stem Cell

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Introduction: Genital ulcers are among the main manifestations of Behçet’s disease (BD); however, large severe acute genital ulcers are not common. Case Presentation: A 29-year-old unmarried woman with a history of recurrent oral aphthae presented with a genital ulcer developed 2 weeks before admission. On clinical examination, there were two large painful ulcerations on the right labia majora, painful oral ulcerations, non-follicular pustules on the face and limbs, and painful edema on the left leg with positive Homan’s sign. The D-dimer level was elevated, and a Doppler ultrasound showed deep venous thrombosis of the right common femoral, femoral, and popliteal veins. The BD was diagnosed according to the International Criteria for Behçet’s Disease. The patient was treated with prednisone 40 mg/day and colchicine 1 mg/day, and the lesions developed well and healed within 2 weeks, leaving scarring lesions in the genital area. Conclusions: Behçet's disease is an important nonvenereal cause of genital ulceration. A high index of suspicion in a patient with mucocutaneous lesions might result in the early diagnosis, management, and prevention of complications.

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Section: Discussionmentioning

confidence: 99%

Severe Acute Genital Ulcer: An Unusual Presentation of Behçet’s Disease: A Case Report

Almheirat,

Kaddar,

Elyamani

et al. 2023

J Skin Stem Cell

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“…It is very rare in the UK with just 11 cases reported in the literature 2–4. There are clear genetic and environmental components to its presentation and pathology and like most autoimmune conditions it is more common in women 5.…”

Section: Discussionmentioning

confidence: 99%

Behcet's disease presenting as new onset of confusion in a male patient of North African origin in the UK

Dolan

Watson²,

Bathgate³

2010

Case Reports

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A 50-year-old right-handed man presented with headache accompanied by new onset confusion and slurring of speech over a 5-day period. This was initially suspected to be due to a transient ischaemic attack. On examination he had a clear ptosis of his left eye, which had developed just 6 days prior to his most recent admission; however, the rest of his neurological examination was normal. A neuropsychiatric review showed poor verbal recall, below average visual contrast ability and below average verbal learning scores. He had a medical history of recurrent oral ulcerations accompanied by anterior uveitus and recurrent genital ulcerations on the scrotum. Imaging showed increased unilateral signal in the left thalamic area, which when taken together with the clinical history, supports the internationally recognised diagnostic criteria for Behçet's disease. The patient lacked insight into his condition meaning that long-term residential care may be required.

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Behcet's disease, painful genital ulcerations and steroid pulse therapy

Cited by 2 publications

References 7 publications

Severe Acute Genital Ulcer: An Unusual Presentation of Behçet’s Disease: A Case Report

Severe Acute Genital Ulcer: An Unusual Presentation of Behçet’s Disease: A Case Report

Behcet's disease presenting as new onset of confusion in a male patient of North African origin in the UK

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