Behavioural, biochemical and molecular changes induced by chronic crack-cocaine inhalation in mice: The role of dopaminergic and endocannabinoid systems in the prefrontal cortex

Areal, Lorena B.; Rodrigues, L. C. M.; Andrich, Filipe; Moraes, Livia S.; Cicilini, Maria Aparecida; Mendonça, Josidéia Barreto; Pelição, Fabrício Souza; Nakamura-Palacios, Ester Miyuki; Martins-Silva, Cristina; Pires, Rita Gomes Wanderley

doi:10.1016/j.bbr.2015.04.036

Cited by 21 publications

(7 citation statements)

References 49 publications

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“…We found that crack induced hyperlocomotion, as previously reported by other groups using different inhalational crack-cocaine models (Areal et al, 2015). Many hypotheses of the exact mechanism of action by which cocaine promotes locomotor activity changes exist, including midbrain α1 adrenergic signaling (Goertz et al, 2014), dopamine D3 receptors (Galaj, Ananthan, Saliba, & Ranaldi, 2014), and a cocaine-andamphetamine-regulated transcript (CART) peptide (Job, Perry, Shen, & Kuhar, 2014).…”

Section: Discussionsupporting

confidence: 57%

A new exposure model to evaluate smoked illicit drugs in rodents: A study of crack cocaine

Hueza

Ponce

Garcia

et al. 2016

Journal of Pharmacological and Toxicological Methods

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Section: Discussionsupporting

confidence: 57%

A new exposure model to evaluate smoked illicit drugs in rodents: A study of crack cocaine

Hueza

Ponce

Garcia

et al. 2016

Journal of Pharmacological and Toxicological Methods

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“…The D3 receptor in particular plays a role in drug seeking and appears to be up-regulated in the abuse of such [20,21,22]. Predominantly found in limbic areas such as the nucleus accumbens and the islands of Calleja, the D3 receptor is, therefore, a prime target for research on drug addiction [23,24,25].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor

et al. 2016

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Cerebral dopamine D3 receptors seem to play a key role in the control of drug-seeking behavior. The imaging of their regional density with positron emission tomography (PET) could thus help in the exploration of the molecular basis of drug addiction. A fluorine-18 labeled D3 subtype selective radioligand would be beneficial for this purpose; however, as yet, there is no such tracer available. F]2a revealed high non-specific uptake in in vitro rat brain autoradiography, the D3 receptor density was successfully determined on rat brain sections (n = 4) with the candidate [ 18 F]2b offering a B max of 20.38 ± 2.67 pmol/g for the islands of Calleja, 19.54 ± 1.85 pmol/g for the nucleus accumbens and 16.58 ± 1.63 pmol/g for the caudate putamen. In PET imaging studies, the carboxamide 1 revealed low signal/background ratios in the rat brain and relatively low uptake in the pituitary gland, while the azocarboxamides [ 18 F]2a and [ 18 F]2b showed binding that was blockable by the D3 receptor ligand BP897 in the ventricular system and the pituitary gland in PET imaging studies in living rats.

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“…They suggested that enhanced expression of D2R short isoform (D2S) in the PFC of such patients or hyperfunctioning NMDA receptors in this region might explain these symptoms. In fact, there is evidence for reduced dopamine tone in the PFC of mice exposed to crack smoke [61]. Areal et al [60] found that upon crack inhalation, mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A, and NR2B NMDA receptor subunits in the PFC.…”

Section: Chronic Psychiatric Effects Of Methamphetaminementioning

confidence: 99%

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

Blum

Cadet

Gold

2021

Journal of the Neurological Sciences

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Background: Approved food and drug administration (FDA) medications to treat Psychostimulant Use Disorder (PUD) are needed. Both acute and chronic neurological deficits related to the neurophysiological effects of these powerfully addictive drugs can cause stroke and alterations in mood and cognition. Objective: This article presents a brief review of the psychiatric and neurobiological sequelae of methamphetamine use disorder, some known neurogenetic associations impacted by psychostimulants, and explores treatment modalities and outcomes. Hypothesis: The authors propose that gentle D2 receptor stimulation accomplished via some treatment modalities can induce dopamine release, causing alteration of D2-directed mRNA and thus enhanced function of D2 receptors in the human. This proliferation of D2 receptors, in turn, will induce the attenuation of craving behavior, especially in genetically compromised high-risk populations. Discussion: A better understanding of the involvement of molecular neurogenetic opioid, mesolimbic dopamine, and psychostimulant connections in "wanting" supports this hypothesis. While both scientific and, clinical professionals search for an FDA approved treatment for PUD the induction of dopamine homeostasis, via activation of the brain reward circuitry, offers treatment for underlying neurotransmitter functional deficits, potential prophylaxis, and support for recovery efforts. Conclusion: Dopamine regulation may help people dig out of their hypodopaminergia ditch.

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Behavioural, biochemical and molecular changes induced by chronic crack-cocaine inhalation in mice: The role of dopaminergic and endocannabinoid systems in the prefrontal cortex

Cited by 21 publications

References 49 publications

A new exposure model to evaluate smoked illicit drugs in rodents: A study of crack cocaine

A new exposure model to evaluate smoked illicit drugs in rodents: A study of crack cocaine

In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

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