Behavioral sensitization to ethanol in rats: evidence from the Sprague–Dawley strain

Hoshaw, Brian A.; Lewis, Michael J.

doi:10.1016/s0091-3057(01)00489-0

Cited by 57 publications

(54 citation statements)

References 31 publications

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“…Repeated activation of the mesolimbic dopamine system may mediate the development of behavioral sensitization to psychomotor stimulants (Vezina and Stewart, 1990;Robinson and Berridge, 1993) and to alcohol (Nesby et al, 1997). Alcohol-induced behavioral sensitization has been shown in human beings (Zack and Vogel-Sprott, 1995), some strains of mice (Masur et al, 1986;Phillips et al, 1997) and in some strains of outbred rats (Hoshaw and Lewis, 2001;Correa et al, 2003); however, the conditions conducive to the induction or expression of behavioral sensitization of locomotor activation in rats remain unclear.…”

Section: Psychomotor Sensitizationmentioning

confidence: 99%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

150

134

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Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian signtracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Signtracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered.

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Section: Psychomotor Sensitizationmentioning

confidence: 99%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

150

134

View full text Add to dashboard Cite

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“…Locomotor sensitization to alcohol has been repeatedly demonstrated in mice (Masur and Boerngen 1980;Roberts et al 1995;Lessov and Phillips 1998;Itzhak and Martin 1999;Souza-Formigioni et al 1999) but less convincingly in rats (Masur et al 1986;Gingras and Cools 1996;Nestby et al 1997;Honkanen et al 1999;Hoshaw and Lewis 2001). Repeated alcohol can, however, produce sensitized dopamine (DA) and acetylcholine (ACh) release in rats, suggesting neural sensitization (Nestby et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice

2002

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“…DA receptor antagonists attenuate the locomotor-activating effects of acute ETOH, suggesting an important role of mesoaccumbal DA neurons in mediating the acute effects of ETOH (Liljequist et al, 1981;Risinger et al, 1992;Shen et al, 1995). Behavioral sensitization after repeated ETOH administration has been demonstrated in rodents (Phillips et al, 1994;Hoshaw and Lewis, 2001;Fish et al, 2002). The role of DA neurons, however, in mediating the development of this adaptive response has received very little attention.…”

Section: Introductionmentioning

confidence: 99%

Repeated Ethanol Intoxication Induces Behavioral Sensitization in the Absence of a Sensitized Accumbens Dopamine Response in C57BL/6J and DBA/2J Mice

Zapata

Gonzales

Shippenberg

2005

Neuropsychopharmacol

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Repeated exposure to drugs of abuse results in an increased sensitivity to their behavioral effects, a phenomena referred to as behavioral sensitization. It has been suggested that the same neuroadaptations underlying behavioral sensitization contribute to the maintenance and reinstatement of addiction. Dysregulation of dopamine (DA) neurotransmission in the mesoaccumbens system is one neuroadaptation that is thought to lead to the compulsive drug-seeking that characterizes addiction. Evidence that sensitization to psychostimulants and opiates is associated with an enhancement of drug-evoked DA levels in the nucleus accumbens has also been obtained. Like other drugs of abuse, the acute administration of ethanol (ETOH) stimulates DA release in this brain region. Moreover, repeated ETOH experience results in an enhanced behavioral response to a subsequent ethanol challenge. Data regarding the influence of repeated ethanol intoxication and withdrawal upon mesoaccumbal DA neurotransmission is limited. Studies examining ETOH-evoked alterations in mesoaccumbal DA neurotransmission as a function of withdrawal duration are lacking. The present experiments quantified basal and ethanol-evoked DA levels 14 days and 24 h following the cessation of a repeated ETOH intoxication protocol, which results in sensitization to the locomotor activating effects of ethanol. Locomotor activity was assessed in parallel groups of animals. Studies were conducted in two mouse strains, C57BL/6J and DBA/2J, which differ in their behavioral responses to ETOH. The results indicate the development of transient tolerance to both ETOH-induced behavioral activation and evoked accumbens DA release at early withdrawal. Moreover, no enhanced DA response to a subsequent ETOH challenge could be demonstrated in ETOH experienced animals 2 weeks after withdrawal, in spite of the observation of clear behavioral sensitization at this time point. These results suggest that, at least in the case of ethanol, sensitization of the DA mesolimbic system may not be necessary for the development of behavioral sensitization.

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Behavioral sensitization to ethanol in rats: evidence from the Sprague–Dawley strain

Cited by 57 publications

References 31 publications

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice

Repeated Ethanol Intoxication Induces Behavioral Sensitization in the Absence of a Sensitized Accumbens Dopamine Response in C57BL/6J and DBA/2J Mice

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