Behavioral characterization of non-copulating male mice

Portillo, Wendy; Antonio-Cabrera, Edwards; Camacho, F.; Díaz, N.F.; Paredes, Raúl G.

doi:10.1016/j.yhbeh.2013.05.001

Cited by 18 publications

(13 citation statements)

References 95 publications

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“…The existence of NC animals in different species confirms the biological variability in sexual motivational drives and allows the opportunity to study and understand the biological bases of asexuality (see below). NC males have been identified in sheep, guinea pigs, gerbils, hamsters, rats and mice (Whalen et al, 1961; Harding and Feder, 1976; Paredes et al, 1990; Alexander et al, 1999; Clark and Galef, 2000; Portillo et al, 2006, 2010, 2013; De Gasperín-Estrada et al, 2008; Borja and Fabre-Nys, 2012; Canseco-Alba and Rodríguez-Manzo, 2013; Mirto et al, 2017; Ventura-Aquino and Paredes, 2017). They represent between 1% and 5% of murine (Portillo et al, 2006, 2013) and 16%–20% of ungulates (Alexander et al, 1999).…”

Section: Motivational Drive In Rodentsmentioning

confidence: 99%

“…Much like males with MPOA lesions, NC male rats, do not have genital dysfunction as they show penile reflexes and spontaneous seminal emission similar to copulating males (Stefanick and Davidson, 1987). Also, NC rats and mice do not have alterations in plasmatic testosterone or estradiol levels that could explain the lack of sexual interest and systemic hormone replacement fails to induce sexual activity (Whalen et al, 1961; Stefanick and Davidson, 1987; Portillo and Paredes, 2003; Portillo et al, 2006, 2013). Although there are no differences in their plasmatic hormonal levels, NC rats have alterations in their steroid receptors.…”

Section: Motivational Drive In Rodentsmentioning

confidence: 99%

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Motivational Drive in Non-copulating and Socially Monogamous Mammals

Portillo

Paredes

2019

Front. Behav. Neurosci.

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Motivational drives guide behaviors in animals of different species, including humans. Some of these motivations, like looking for food and water, are crucial for the survival of the individual and hence for the preservation of the species. But there is at least another motivation that is also important for the survival of the species but not for the survival of the individual. Undoubtedly, sexual motivation is important for individuals to find a mate and reproduce, thus ensuring the survival of the species. In species with sexual reproduction, when males find a female in the appropriate hormonal conditions, they will display sexual behavior. However, some healthy males do not mate when they have access to a sexually receptive female, even though they are repeatedly tested. These non-copulating (NC) individuals have been reported in murine, cricetid and ungulates. In humans this sexual orientation is denominated asexuality. Asexual individuals are physically and emotionally healthy men and women without desire for sexual intercourse. Different species have developed a variety of strategies to find a mate and reproduce. Most species of mammals are polygamous; they mate with one or several partners at the same time, as occur in rats, or they can reproduce with different conspecifics throughout their life span. There are also monogamous species that only mate with one partner. One of the most studied socially monogamous species is the Prairie vole. In this species mating or cohabitation for long periods induces the formation of a long-lasting pair bond. Both males and females share the nest, show a preference for their sexual partner, display aggression to other males and females and display parental behavior towards their pups. This broad spectrum of reproductive strategies demonstrates the biological variability of sexual motivation and points out the importance of understanding the neurobiological basis of sexual motivational drives in different species.

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Section: Motivational Drive In Rodentsmentioning

confidence: 99%

Section: Motivational Drive In Rodentsmentioning

confidence: 99%

Motivational Drive in Non-copulating and Socially Monogamous Mammals

Portillo

Paredes

2019

Front. Behav. Neurosci.

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“…Urine of Wistar males or receptive female Wistar rats was used as the source of socially or sexually significant odor stimulus, respectively. We used male urine as a socially significant scent since male urine or bedding odor vs. receptive female urine or bedding odor was widely used to test olfactory preference of sexually significant stimulus in male rats or mice, and there was a clear difference in behavioral response of males to a receptive female odor vs. a male odor [20][21][22][23][24], even in sexually naïve males [20,21].…”

Section: General Proceduresmentioning

confidence: 99%

Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI

Tikhonova

Romaschenko

Akulov

et al. 2015

Behavioural Brain Research

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“…There are also a small number of males, in different species, that will not mate despite being tested repeatedly with receptive females; these are identified as noncopulating males (NC; see Antonio‐Cabrera and Paredes, and Portillo et al. [8,9]).…”

Section: Introductionmentioning

confidence: 99%

Steroid Receptors and Aromatase Gene Expression in Different Brain Areas of Copulating and Sexually Sluggish Male Rats

Antaramián

González‐Gallardo

García‐Ugalde

et al. 2015

The Journal of Sexual Medicine

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Introduction Sexually sluggish (SS) males have been identified in several species of mammals including rats. These animals take more than 30 minutes to ejaculate; they do not ejaculate or do so inconsistently despite being tested repeatedly with sexually receptive females. Different brain areas and hormones play an important role in the control of male sexual behavior. Aims Determine gene expression for the androgen receptor (AR), the estrogen receptor alpha (ERα), the progesterone receptor (PR), and the aromatase enzyme (ARO), in brain regions important in the control of male sexual behavior including the medial preoptic area (MPOA), the amygdala (AMG), the olfactory bulb (OB), and, as a control, the cortex (CTX) of copulating (C) and SS male rats. Methods Males that ejaculated within 30 minutes in three tests with receptive females were included in the C group, while those males that ejaculated in one or none of the four tests were included in the SS group. RNA was isolated 1 week after the last test of sexual behavior, and cDNA was synthesized from the brain areas listed above. Main Outcomes Measures Expression of the AR, ERα, PR, and ARO genes was determined by quantitative polymerase chain reaction (qPCR). Cyclophilin A (CycA) and tyrosine 3-monooxygenase-tryptophan activation protein zeta (Ywhaz) were housekeeping genes used to determine relative gene expression with the 2−ΔΔCt method. Results The expression of mRNA for AR and ARO increased in the MPOA of SS males. ARO mRNA was increased in the AMG of SS males. In the OB, ERα mRNA was increased and AR mRNA reduced in SS males. Conclusion These results indicate SS and C males show differences in gene expression within brain regions controlling sexual behavior.

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Behavioral characterization of non-copulating male mice

Cited by 18 publications

References 95 publications

Motivational Drive in Non-copulating and Socially Monogamous Mammals

Motivational Drive in Non-copulating and Socially Monogamous Mammals

Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI

Steroid Receptors and Aromatase Gene Expression in Different Brain Areas of Copulating and Sexually Sluggish Male Rats

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