Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats

Masís-Calvo, Marianela; Sequeira‐Cordero, Andrey; Mora-Gallegos, Andrea; Trías, Jaime Fornaguera

doi:10.1016/j.physbeh.2013.05.033

Cited by 24 publications

(28 citation statements)

References 63 publications

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“…In the present and previous study(Marques-Carneiro et al, 2014) most parameters measured inWistars sometimes differed from NECs and sometimes from GAERS, while the consequences of early life environment should be rather consistent, and thus concordant(Weaver et al, 2006;Masís-Calvo et al, 2013;Sakhai et al, 2013). This indicates that early life environment cannot be the only cause of the differences recorded in this study.…”

supporting

confidence: 69%

“…GAERS and NECs were born and raised under the exact same environmental conditions while Wistars were provided by a commercial breeder. Therefore, despite a general respect of strict national and international guidelines, which contributes to level rearing conditions, it cannot be excluded that gestation and early postnatal environmental conditions may have differed between Wistars and the two genetic groups in a way that could partly impact on the herein reported differences (Weaver et al, 2006;Masís-Calvo et al, 2013;Sakhai et al, 2013 …”

Section: Limitations Of the Studymentioning

confidence: 95%

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Subtle alterations in memory systems and normal visual attention in the GAERS model of absence epilepsy

et al. 2016

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supporting

confidence: 69%

Section: Limitations Of the Studymentioning

confidence: 95%

Subtle alterations in memory systems and normal visual attention in the GAERS model of absence epilepsy

et al. 2016

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“…At the time of weaning (PND 21), male offspring that have experienced low-LG have continued reductions in hippocampal BDNF and NMDAR subunit expression [31; 36] as well as reduced synaptophysin and NCAM protein levels leading to reduced neuronal survival [31; 56]. Amongst juvenile (PND 40) male offspring of low-LG rat dams, altered serotonin (5-HT) turnover rates are apparent in the PFC, ventral striatum, and hippocampus [57; 58]. In female offspring, variation in protein and mRNA levels within the MPOA and VTA associated with maternal LG can be observed as early as PND 6.…”

Section: Neurobiological and Behavioral Impact Of Variation In Matmentioning

confidence: 99%

“…The early emergence of these neurobiological effects of maternal care may account for the behavioral phenotypes that also emerge prior to adulthood. Juvenile male offspring of low-LG dams exhibit increased indices of anxiety-like behavior [57] and low-LG female offspring display decreased maternal sensitivity to donor pups [17]. Though these developmental studies do provide some insight into the timing of neurobiological change as a consequence of variation in maternal care, a more systematic use of this approach, in which brain-region specific changes in gene expression/protein are assessed at multiple timepoints during development, will be needed to understand the process by which maternal care induces long-term effects.…”

Section: Neurobiological and Behavioral Impact Of Variation In Matmentioning

confidence: 99%

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

Curley

Champagne

2016

Frontiers in Neuroendocrinology

206

117

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Variation in maternal care can lead to divergent developmental trajectories in offspring with implications for neuroendocrine function and behavioral phenotypes. Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences. Through integration of genetic, molecular, cellular, neuroanatomical, and neuroendocrine approaches, significant advances in our understanding of these complex pathways have been achieved. In this review, we will consider the impact of maternal care on male and female offspring development with a particular focus on the issues of timing and mechanism. Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study of mechanism.

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“…It is well-known that the serotonergic system is involved in the regulation of mood, stress, aggressive behaviour and mental disorders in humans and other species [34,82]. In pigs, a decrease in 5-HT has been associated to negative states as stress, fear and aggression [33,83–86] whereas an increase in 5-HT in the PFC has been related to positive conditions in the rat [87,88]. Controversial results have been reported for the amygdala [89,90].…”

Section: Discussionmentioning

confidence: 99%

Effects on pig immunophysiology, PBMC proteome and brain neurotransmitters caused by group mixing stress and human-animal relationship

et al. 2017

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Peripheral blood mononuclear cells (PBMC) are an interesting sample for searching for biomarkers with proteomic techniques because they are easy to obtain and do not contain highly abundant, potentially masking proteins. Two groups of pigs (n = 56) were subjected to mixing under farm conditions and afterwards subjected to different management treatments: negative handling (NH) and positive handling (PH). Serum and PBMC samples were collected at the beginning of the experiment one week after mixing (t0) and after two months of different handling (t2). Brain areas were collected after slaughter and neurotransmitters quantified by HPLC. Hair cortisol and serum acute phase proteins decreased and serum glutathione peroxidase increased at t2, indicating a lower degree of stress at t2 after adaptation to the farm. Differential gel electrophoresis (DIGE) was applied to study the effects of time and treatment on the PBMC proteome. A total of 54 differentially expressed proteins were identified, which were involved in immune system modulation, cell adhesion and motility, gene expression, splicing and translation, protein degradation and folding, oxidative stress and metabolism. Thirty-seven protein spots were up-regulated at t2 versus t0 whereas 27 were down-regulated. Many of the identified proteins share the characteristic of being potentially up or down-regulated by cortisol, indicating that changes in protein abundance between t0 and t2 are, at least in part, consequence of lower stress upon adaptation to the farm conditions after group mixing. Only slight changes in brain neurotransmitters and PBMC oxidative stress markers were observed. In conclusion, the variation in hair cortisol and serum APPs as well as the careful analysis of the identified proteins indicate that changes in protein composition in PBMC throughout time is mainly due to a decrease in the stress status of the individuals, following accommodation to the farm and the new group.

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Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats

Cited by 24 publications

References 63 publications

Subtle alterations in memory systems and normal visual attention in the GAERS model of absence epilepsy

Subtle alterations in memory systems and normal visual attention in the GAERS model of absence epilepsy

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

Effects on pig immunophysiology, PBMC proteome and brain neurotransmitters caused by group mixing stress and human-animal relationship

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