Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats

Nagyéri, György; Valkusz, Zsuzsanna; Radács, Marianna; Ocskó, Tímea; Hausinger, Péter; László, M.; László, Ferenc; Juhász, Anna; Julesz, J.; Gálfi, Márta

doi:10.1016/j.ntt.2011.09.011

Cited by 17 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Subsequent work revealed that perinatal oral exposure to 1.7 or 30.6 mg/kg/day resulted in elevated systolic blood pressure responses at 3 h post-hyperosmotic challenge, an effect the authors interpreted as possibly attributable to decreased plasma AVP levels (78). A single paper also suggests that long-term exposure to chlorobenzenes (solvents) may also disrupt neurohypophysial AVP and OT release (149). Complementary work by multiple research teams has identified NO signaling as a potent target of many EDCs including PBDEs, PCBs, and other organohalogens (representative examples include (74, 150, 151)) suggesting another possible route by which EDCs could impact AVP function.…”

Section: Avp Impacts—beyond Brain and Behaviormentioning

confidence: 99%

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Patisaul

2017

Front. Endocrinol.

View full text Add to dashboard Cite

Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants. Many effects are sex specific and likely involve action at nuclear estrogen receptors. Effects include the elimination or reversal of well-characterized sexually dimorphic aspects of the AVP system, including innervation of the lateral septum and other brain regions critical for social and other non-reproductive behaviors. Disruption of magnocellular AVP function has also been reported in rats, suggesting possible effects on hemodynamics and cardiovascular function.

show abstract

Section: Avp Impacts—beyond Brain and Behaviormentioning

confidence: 99%

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Patisaul

2017

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The OT and AVP contents were detected in the supernatant media. From the supernatant media, 500 μ L samples were removed by Gilson pipette at appropriate times and stored at −80°C until peptide radioimmunoassay (RIA) was performed to measure OT and AVP [10, 37].…”

Section: Methodsmentioning

confidence: 99%

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro

Sepp

Molnár

László

et al. 2019

International Journal of Endocrinology

View full text Add to dashboard Cite

Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g., by altering hormone regulation, membrane functions) and/or indirect (e.g., cell transformation mechanisms) factors, they are classified as EDC. We aimed to examine the potential endocrine-disrupting effects of phenylurea herbicides (phenuron, monuron, and diuron) on the oxytocin (OT) and arginine-vasopressin (AVP) release of neurohypophysis cell cultures (NH). In our experiments, monoamine-activated receptor functions of neurohypophyseal cells were used as a model. In vitro NH were prepared by enzymatic (trypsin, collagenase) and mechanical dissociation. In the experimental protocol, the basal levels of OT and AVP were determined as controls. Later, monoamine (epinephrine, norepinephrine, serotonin, histamine, and dopamine) activation (10−6 M, 30 min) and the effects of phenylurea (10−6 M, 60 min) alone and in combination (monoamines 10−6 M, 30 min + phenylureas 10−6 M, 60 min) with monoamine were studied. OT and AVP hormone contents in the supernatant media were measured by radioimmunoassay. The monoamine-activated receptor functions of neurohypophyseal cells were modified by the applied doses of phenuron, monuron, and diuron. It is concluded that the applied phenylurea herbicides are endocrine disruptor agents, at least in vitro for neurohypophysis function.

show abstract

“…állat-vagy humán gyógyászatban a fixálódó negatív fiziológiai események kapcsán betegségekhez vezethetnek. A vázolt generális betegségek sejtszinten is detektálható eltérésekkel jellemezhetők [22,23,24].…”

Section: A Környezetterhelések éS Homeosztatikus Válaszmechanizmusokunclassified

“…a viselkedésmintázatok változásai is ilyen hatáskövetkezmények lehetnek). Lehetséges, hogy akut és alacsony dózisú környezeti expozíciók után még nem detektálhatók szignifikáns magatartásváltozások, de trend eltérések igen [22,26]. A krónikus expozíciók, melyek kis változásokat kiváltó hatásokat jelentenek, már fiziológiai diszfunkciókat is okozhatnak (pl.…”

Section: áBra Gyulladásos Folyamatkaszkád [25] (Il-1: Interleukin 1unclassified

A környezeti terhelések és patomechanizmusok kapcsolata

Pálföldi

View full text Add to dashboard Cite

Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats

Cited by 17 publications

References 52 publications

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro

A környezeti terhelések és patomechanizmusok kapcsolata

Contact Info

Product

Resources

About