Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety

Li, Heng; Ohta, Hidenobu; Izumi, Hitomi; Matsuda, Yoshiki; Seki, Mika; Toda, Takako; Akiyama, Misaki; Matsushima, Yohkazu; Goto, Yu‐ichi; Kaga, Makiko; Inagaki, Masumi

doi:10.1016/j.bbr.2012.09.051

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…More specifically, the large majority of GABAergic CB1-containing neurons is cholecystokininergic (Marsicano and Lutz 1999 ; McDonald and Mascagni 2001 ; Katona et al 2001 ). Cholecystokinin has well-known anxiogenic effects, at least in part via the amygdala and prefrontal cortex (Bowers et al 2012 ; Li et al 2013 ; Vialou et al 2014 ), and thus restored CB1 receptor expression in these neurons may reduce anxiety-like behavior via a reduction of cholecystokinin release. This is in accordance with an anxiolytic effect of stimulation of the CB1 receptor in the prefrontal cortex with low doses of cannabinoids (Rubino et al 2008a , b ).…”

Section: Discussionmentioning

confidence: 99%

Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons

Remmers

Lange²,

Hamann

et al. 2017

Brain Struct Funct

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Genetic inactivation of the cannabinoid CB1 receptor gene in different cell types in the brain has previously revealed necessary functions for distinct synaptic plasticity processes and behaviors. Here, we sought to identify CB1 receptor expression sites that are minimally required to reconstruct normal phenotypes. In a CB1-null background, we re-expressed endogenous CB1 receptors in forebrain GABAergic neurons, thereby assessing the sufficiency of CB1 receptors. Depolarization-induced suppression of inhibitory, but not excitatory, transmission was restored in hippocampal and amygdalar circuits. GABAergic CB1 receptors did not convey protection against chemically induced seizures, but prevented the spontaneous mortality observed in CB1 null mutants. Rescue of GABAergic CB1 receptors largely restored normal anxiety-like behavior but improved extinction of learned fear only marginally. This study illustrates that the approach of genetic reconstruction of complex behaviors is feasible. It also revealed distinct degrees of modulation for different emotional behaviors by the GABAergic population of CB1 receptors.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-017-1411-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons

Remmers

Lange²,

Hamann

et al. 2017

Brain Struct Funct

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“…Neuropeptides' role in ADs have been extensively studied in animal and human samples, underlying their role in the pathophysiology of ADs and as promising new targets for treatment interventions [75,76]. The most important neuropeptides that play a role in the modulation of stress-related behaviors and anxiety are cholecystokinin (CCK) [77][78][79], oxytocin (OXT) [80][81][82][83], substance P [84], neuropeptide Y, galanin [76], pituitary adenylate activator polypeptide (PACAP) [85,86], ghrelin [87], and leptin [88].…”

Section: Neuropeptidesmentioning

confidence: 99%

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

et al. 2020

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Anxiety disorders are prevalent and highly disabling mental disorders. In recent years, intensive efforts focused on the search for potential neuroimaging, genetic, and peripheral biomarkers in order to better understand the pathophysiology of these disorders, support their diagnosis, and characterize the treatment response. Of note, peripheral blood biomarkers, as surrogates for the central nervous system, represent a promising instrument to characterize psychiatric disorders, although their role has not been extensively applied to clinical practice. In this report, the state of the art on peripheral biomarkers of DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th edition) Anxiety Disorders is presented, in order to examine their role in the pathogenesis of these conditions and their potential application for diagnosis and treatment. Available data on the cerebrospinal fluid and blood-based biomarkers related to neurotransmitters, neuropeptides, the hypothalamic–pituitary–adrenal axis, neurotrophic factors, and the inflammation and immune system are reviewed. Despite the wide scientific literature and the promising results in the field, only a few of the proposed peripheral biomarkers have been defined as a specific diagnostic instrument or have been identified as a guide in the treatment response to DSM-5 Anxiety Disorders. Therefore, further investigations are needed to provide new biological insights into the pathogenesis of anxiety disorders, to help in their diagnosis, and to tailor a treatment.

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“…The CCK2 receptor is expressed highly in regions modulating pain and fear/emotional processing (Bowers et al, 2012;Chen et al, 2010;Kurrikoff et al, 2004;Li et al, 2013). In preclinical studies, deletion of the CCK2 receptor decreased hyperalgesia in a mouse neuropathic pain model (Kurrikoff et al, 2004), and ablation (CCK2 knockout mice) of the receptor increased μ-and δ-opioid receptors expression in the whole brain (Pommier et al, 2002).…”

Section: Cholecystokinin (Cck)mentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety

Cited by 20 publications

References 33 publications

Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons

Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

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