Behavior of melanocytes in reticulate acropigmentation of Kitamura

Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura

“…Light microscopic findings in this case were consistent with that of previously reported cases, that is, slight hyperkeratosis without parakeratosis, elongation of the rete ridges, increased number of melanocytes, and pigmentation in the lower epidermis without obvious incontinentia pigmenti in the dermis (Kono et al, 2013;Mizoguchi and Kukita, 1985). The composition of multiple Melan-A expressing dots shown in Figure 2D may either be numerous melanosome complexes in keratinocytes, as seen by our electron microscopy study (Figure 2E, F), or an accumulation of melanosomes in melanocyte dendrites as described by Mizoguchi and Kukita (1985). Melanosome complexes without a membranous structure were also detected in melanocytes.…”

“…Subsequently, ADAM10 has been recognized as a causative gene for RAK. A few papers have described the disease at the ultrastructural level (Kameyama et al, 1992;Mizoguchi and Kukita, 1985). Here we identify a novel ADAM10 mutation in a RAK family and present for the first time an electron microscopic study of samples obtained from a genetically identified patient.…”

Bony Anomalies in a Patient with Reticulate Acropigmentation of Kitamura

“…The first cases reported in the English literature were published by Griffiths in 1976 (2). Several case reports followed Griffiths' work but the total cases reported in the English literature are less than 15 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). This is a report of a case in which hitherto undescribed bone anomalies were found.…”

Reticulate Acropigmentation of Dohi: First Case Reports from Nepal

“…The lesions usually progress until adolescence and then remain the same throughout the rest of life (6). Histologically, there is epidermal atrophy and an increase in the number of basal melanocytes (7).…”