Behavior of corneal endothelial density over a lifetime

Abstract

Knowing the representative values of endothelial density and the probabilities of occurrence over a lifetime can help surgeons determine the risk to the cornea of anterior segment surgery. It can also be useful in following eyes with disease affecting the endothelium and in preparing and evaluating corneal specular microscopy reports.

Non-contact specular microscopy in aphakic and pseudophakic dogs

“…A signifi cant difference was observed between groups immediately after surgery (G1=23.4±9.74; G2=46.0±9.04), day 7 (G1=18.9±7.72; G2=45.6±5.19), day 30 (G1=15.5±9.01; G2=61.1±3.69), day 45 (G1=14.5±7.98; G2=62.4±3.41) and day 60 (G1=28.3±10.15; G2=70.8±4.06) after phacoemulsifi cation. RODRIGUES (1999) and ABIB & BARRETOS (2001) showed that corneal cell density decreases with age. Besides aging infl uence, several factors, such as trauma and intraocular infl ammation, may lead to endothelial loss (TUFT & COSTER, 1990;PIGATTO et al, 2005).…”

Scanning electron microscopy of the corneal endothelium of ostrich

“…The structure of the normal corneal endothelium has been documented in humans (ABIB & BARRETO, 2001), dogs (GWIN et al, 1982;PIGATTO et al, 2006;RODRIGUES et al, 2006), horses (ANDREW et al, 2001) and other animal species (YEE et al, 1987;COLLIN & COLLIN, 1998;PIGATTO et al, 2004;PIGATTO et al, 2005a;PIGATTO et al, 2005b). The ostrich (Struthio camelus) is the world's largest living bird.…”

Corneal endothelial cell density and morphology in rabbits’ eyes using contact specular microscopy

“…Due to the fact that there is no cellular retraction and it can be used in animals and living humans, specular microscopy is considered the gold standard technique for assessing the corneal endothelium in people and animals (MORITA, 1995;ABIB & BARRETO, 2001;PIGATTO et al, 2006;PIGATTO et al, 2008;FRANZEN et al, 2010;BERCHT et al, 2015;ALBUQUERQUE et al, 2015;COYO et al, 2016). Specular microscopy has also been employed in the evaluation of dogs undergoing cataract removal surgery (NAGATSUYU et al, 2014).…”

“…The goal of the present study was to evaluate the cell density and percentage of hexagonal cells because these are the most reliable parameters for evaluating the integrity of the corneal endothelium (ABIB & BARRETO, 2001;PIGATTO et al, 2006;NAGATSUYU et al, 2014). SAILSTAD and PEIFFER (1981) observed the corneal endothelium of 14 young adult rabbits using a specular microscope.…”

“…Endothelial layer is of fundamental importance in maintaining the transparency of the cornea and changes in endothelial cells can occur due to aging, eye diseases, drugs or intraocular surgery. Specular microscopy is among the most reliable techniques for analysing the corneal endothelium (ABIB & BARRETO, 2001;NAGATSUYU et al, 2014). Normal endothelial parameters have already been established in some species using a specular microscope, including: humans, sheep, dogs, monkeys, horses, cats, and others (ABIB & BARRETO, 2001;ANDREW, S. et al 2001;PIGATTO et al, 2006;PIGATTO et al, 2008;FRANZEN et al, 2010;BERCHT et al, 2015;COYO et al, 2016;TERZARIOL et al, 2016).…”