The purpose of this research is to explore the principle of the man-object relationship to identify the issues shown when handling packaging and emphasizing the usability aspect. For that, the theoretical reference of the research involves the analysis of the parameters according to the aspects that involve the use interactions of packaging in agreement with the definition and scientific concepts of ergonomics, allied to the development of product projects, discussing forms, handling, load transportation and the support of the product. Therefore, improperly handling of the packaging may cause damages to the products and even potential accidents. Coding and decoding are significant to facilitate the use recognition within the individual's repertoire. The packaging, within the macro-ergonomics universe, may be the object of ergonomics, whose contribution to solve problems is related to labor activities, by dealing with packaging, transportation and load resulting from the man-object interaction. The incorrect identification of information may lead to problems of interpretation and misuse, from the handling to the disposal of packaging. For this reason, this research suggests the adjustment of the man-object interface which may lead users to make mistakes regarding use and important choices, through adequate handling actions.