To the editor Skin is one of the most commonly affected organs by the SARS-CoV-2 infection. Different manifestations including skin, mucous membranes and hair have been reported. 1 Until recently, not many articles incorporate nail manifestations of COVID-19. 2 We conducted a literature search in Pubmed, Embase, The Cochrane Library, EBSCO and Google scholar databases regarding all the case reports and series of nail changes associated to COVID-19 infection. Included cases are summarized in Table 1.A total of six case reports were found: two reported beau lines, 3,4 two red half-moon nail sign, 2,5 one onychomadesis 1 and one a distal orange discoloration. 6 Median age was of 53.5 years (range 37 to 89 years). Four patients were females and two males. Median time of onset of nail manifestations after the diagnosis of COVID-19 was of 56 days (range 2 to 112 days). The earliest manifestations were red half-moon nail sign, 2 and 14 days after diagnosis, and the latest the distal orange discoloration. Beau lines appeared after 28 and 98 days and onychomadesis after 84 days. Different COVID-19 symptoms were described, and the most frequently found was fever, which was present in four patients. After this, dyspnoea and cough were reported in three patients each. Other found symptoms were diarrhoea, anosmia, ageusia and sore throat. Of the six included