Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

Ho, Chung-Shun

doi:10.12809/hkmj176834

Cited by 6 publications

(8 citation statements)

References 65 publications

(80 reference statements)

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“…The treatment methods for NPC mainly include radiation therapy and chemotherapy, and a small number of cases are supplemented by surgery [6]. Because of intrinsically insidious anatomical location of NPC tumor, radiation therapy is the optimal choice in clinical practices [4,[6][7][8][9][10]. The main effect of radiotherapy is to induce the apoptosis of tumor cells via directly or indirectly damaging the cell's nucleic acid [11,12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the radiotherapy effect for nasopharyngeal cancer using plasma surface-enhanced Raman spectroscopy technology

Wu¹,

Qiu²,

Yu³

et al. 2018

Biomed. Opt. Express

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Nasopharyngeal cancer (NPC) is a malignant tumor of the head and neck, which is extremely sensitive to radiotherapy. The aim of this study is to evaluate the feasibility of a label-free nanobiosensor based on plasma surface-enhanced Raman spectroscopy (SERS) to assess the radiotherapy effect in NPC. Here, SERS measurements were performed on plasma samples from 40 pre-treatment and post-treatment NPC as well as 30 healthy volunteers. Results demonstrate that the spectral characteristic of post-treatment samples is obviously different from that of pre-treatment ones, owing to the changes of biomolecules in plasma induced by radiotherapy. Classification sensitivities of 83.3%, 61.8% and 95.1%, and specificities of 91.2%, 67.4% and 93% can be achieved for separating pre- and post-treatment samples, post-treatment and normal samples, and pre-treatment and normal samples, respectively, suggesting the great potential of plasma SERS method as a rapid and convenient tool for radiotherapy assessment and cancer screening in NPC.

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Section: Introductionmentioning

confidence: 99%

Assessment of the radiotherapy effect for nasopharyngeal cancer using plasma surface-enhanced Raman spectroscopy technology

Wu¹,

Qiu²,

Yu³

et al. 2018

Biomed. Opt. Express

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“…NPC has been managed through IMRT, combined radiotherapy, and chemotherapy, which improve the 5-year overall survival of patients with NPC. [1][2][3][4][5] Distant metastasis remains the main reason behind treatment failure. 5 Therefore, exploring the molecular mechanisms related to the invasion and metastasis of NPC and finding new targets for intervention are the major challenges that must be overcome.…”

Section: Discussionmentioning

confidence: 99%

“…Nasopharyngeal carcinoma (NPC) is an important malignant tumor of the head and neck and etiologically relevant to the Epstein-Barr virus. 1,2 NPC has a specific geographic distribution characterized by high incidence in south China, Southeast Asia, and North Africa. 2,3 Although intensity-modulated radiation therapy (IMRT) and comprehensive chemotherapy strategies have been widely used, distant metastasis and recurrence manifest as the dominant pattern of disease relapse in locoregionally advanced NPC.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 NPC has a specific geographic distribution characterized by high incidence in south China, Southeast Asia, and North Africa. 2,3 Although intensity-modulated radiation therapy (IMRT) and comprehensive chemotherapy strategies have been widely used, distant metastasis and recurrence manifest as the dominant pattern of disease relapse in locoregionally advanced NPC. [3][4][5] Therefore, the mechanisms of invasion and migration and efficient therapeutic targets for NPC should be explored.…”

Section: Introductionmentioning

confidence: 99%

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<p>ZNRD1-AS1 Promotes Nasopharyngeal Carcinoma Cell Invasion and Metastasis by Regulating the miR-335–ROCK1 Axis</p>

Wang

et al. 2020

OTT

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Background: Long noncoding RNAs (lncRNAs) are known as key regulators in many cancer types, but their biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we aim to explore the role of the lncRNA ZNRD1-AS1 in NPC tumor development. Methods: The role of ZNRD1-AS1 in NPC tissues and cells was explored by using quantitative real-time PCR assay. Cellular behavioral experiments were used in testing NPC cell proliferation, invasion, and migration. Luciferase reporter assay, RNA-binding protein immunoprecipitation, and Western blot analysis were used in estimating the associations among ZNRD1-AS1, miR-335, and ROCK1. Results: ZNRD1-AS1 expression was elevated in the NPC tissues and cells, and ZNRD1-AS1 overexpression was positively correlated with advanced TNM stage and the presence of lymph node metastasis. Our biological experiments indicated that ZNRD1-AS1 knockdown reduces NPC cell invasion and metastasis. Further analyses revealed that ZNRD1-AS1 as a ceRNA promotes the migration and invasion of NPC cells by sponging miR-335. We provided evidence that ZNRD1-AS1 facilitates the invasion and metastasis of NPC cells via the miR-335-ROCK1 axis. Conclusion: Our data shed light on the oncogenic role of ZNRD1-AS1 in NPC tumor development, and a promising therapeutic target for NPC was identified.

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“…This might reflect the fact that NPC is a rare malignancy in most parts of the world, while its occurrence in Southeast Asia is considerably high: the age-standardized incidence rate (ASR) is up to 14.0 in southern China, 9.2 in Malaysia, and 7.9 in Hong Kong, compared with less than 1.0 per 100,000 inhabitants in North America and Europe. 42-44 Furthermore, many cities in Southeast Asia with the highest industrial concentrations are also characterized by high concentrations of pollutants and intake of locally consumed traditional preserved food that might be triggers for the process of formation of NPC. 45,46 Above all, there have been reported differences in survival, with a disease-specific survival advantage for Asian ethnicity compared with Caucasian patients.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta‐analysis of SNPs from Genome‐Wide Association Studies of Head and Neck Cancer

Vuković

Stojanovic

Vecchioni

et al. 2018

Otolaryngol.--head neck surg.

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Objective Various genome-wide association studies (GWASs) identified new head and neck cancer (HNC) susceptibility loci, although the evidence has not been systematically summarized. We performed a systematic review and meta-analyses of the GWASs to identify the most commonly reported genetic loci associated with a risk of HNC. Data Sources We searched the PubMed, ISI Web of Science, SCOPUS, and GWAS databases to retrieve eligible studies, in English or Italian, published until June 1, 2017. Review Methods Only GWASs reporting data on the association between single-nucleotide polymorphisms (SNPs) and HNC were included. The quality of included studies was evaluated using the Q-Genie tool. Random-effect meta-analyses were performed considering only SNPs with at least 1 significant result from the included articles, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results Seven studies of case-control design were included in the review. Five studies on nasopharyngeal cancer (NPC) in Chinese, reporting on 27 different SNPs, were included in meta-analyses. Results show that 6 SNPs ( rs2076483, rs2975042, rs9258122, rs29232, and rs9510787) had an increased pooled estimates for A risk alleles (OR [95% CI]: 1.55 [1.36-1.77], 1.90 [1.69-2.14], 1.47 [1.31-1.65], 1.52 [1.32-1.76], and 1.22 [1.13-1.31], respectively) while G risk allele of rs3129055 reported an OR of 1.49 (95% CI, 1.33-1.67). Conclusion Our systematic review identified 5 SNPs located on chromosome 6 ( rs2076483, rs2975042, rs3129055, rs9258122, and rs29232) and 1 ( rs9510787) on chromosome 13 as significantly associated with an increased risk of NPC in Chinese.

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Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

Cited by 6 publications

References 65 publications

Assessment of the radiotherapy effect for nasopharyngeal cancer using plasma surface-enhanced Raman spectroscopy technology

Assessment of the radiotherapy effect for nasopharyngeal cancer using plasma surface-enhanced Raman spectroscopy technology

<p>ZNRD1-AS1 Promotes Nasopharyngeal Carcinoma Cell Invasion and Metastasis by Regulating the miR-335–ROCK1 Axis</p>

Systematic Review and Meta‐analysis of SNPs from Genome‐Wide Association Studies of Head and Neck Cancer

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