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Cited by 3 publications
(2 citation statements)
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“…The term trained immunity refers to the phenomenon that occurs when, after exposure to a pathogen, the cells of the innate immune system (monocytes, macrophages, NK cells, etc.) are capable of mounting a heightened, nonspecific response against a broad range of pathogens in the case of secondary exposure [ 3 , 4 ]. In the initiation of trained immune phenotype, stimulation by various pattern recognition receptors results in genome wide epigenetic changes in these cells.…”
Section: Trained Immunitymentioning
confidence: 99%
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“…The term trained immunity refers to the phenomenon that occurs when, after exposure to a pathogen, the cells of the innate immune system (monocytes, macrophages, NK cells, etc.) are capable of mounting a heightened, nonspecific response against a broad range of pathogens in the case of secondary exposure [ 3 , 4 ]. In the initiation of trained immune phenotype, stimulation by various pattern recognition receptors results in genome wide epigenetic changes in these cells.…”
Section: Trained Immunitymentioning
confidence: 99%
“…In the initiation of trained immune phenotype, stimulation by various pattern recognition receptors results in genome wide epigenetic changes in these cells. This process leads to an altered transcriptional profile and the rewiring of the cellular metabolism [ 4 ], shifting from oxidative phosphorylation towards glycolytic processes (Warburg effect) [ 3 ]. Compared to their unexposed counterparts, these primed cells are more effective at eliminating infections both by direct (phagocytosis) and indirect (IL-1β, IL-6, TNF-α, and other cytokine production) mechanisms [ 5 ].…”
Section: Trained Immunitymentioning
confidence: 99%