2013
DOI: 10.1038/tp.2013.30
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Abstract: The therapeutic activity of selective serotonin (5-HT) reuptake inhibitors (SSRIs) relies on long-term adaptation at pre- and post-synaptic levels. The sustained administration of SSRIs increases the serotonergic neurotransmission in response to a functional desensitization of the inhibitory 5-HT1A autoreceptor in the dorsal raphe. At nerve terminal such as the hippocampus, the enhancement of 5-HT availability increases brain-derived neurotrophic factor (BDNF) synthesis and signaling, a major event in the stim… Show more

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Cited by 197 publications
(132 citation statements)
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“…5) although a possible drop in the gene expression may not be discarded. This does not preclude that BDNF acts on neuronal homeostasis: as it has recently been shown that BDNF synthetized in hippocampal astrocytes acts in a paracrine manner on the adjacent neurons (Quesseveur et al, 2013). Together, these results support the idea that OB could supply at least a part of the BDNF protein to the OE through ORN axonal transportation during an OE regeneration promoting the massive differentiation and maturation of ORNs due to the loss of SUS cells (Uranagase et al, 2012).…”
Section: Discussionsupporting
confidence: 54%
“…5) although a possible drop in the gene expression may not be discarded. This does not preclude that BDNF acts on neuronal homeostasis: as it has recently been shown that BDNF synthetized in hippocampal astrocytes acts in a paracrine manner on the adjacent neurons (Quesseveur et al, 2013). Together, these results support the idea that OB could supply at least a part of the BDNF protein to the OE through ORN axonal transportation during an OE regeneration promoting the massive differentiation and maturation of ORNs due to the loss of SUS cells (Uranagase et al, 2012).…”
Section: Discussionsupporting
confidence: 54%
“…The delay is reduced by acute knockdown of SERT that leads to enhanced serotonin release accompanied by increased neurotrophic signaling and neurogenesis (Ferres-Coy et al, 2013). Further, therapeutic activity of antidepressant drugs might result from an increase in BDNF synthesis in astrocytes (Quesseveur et al, 2013).…”
Section: Neurogenesis/monoamine/neurotrophin Hypothesis Of Antidepresmentioning
confidence: 99%
“…The procedure lasted for 2 min and 39 s, delivering a total of 2.5 Gy. Three 2.5 Gy doses were delivered on days 1, 4, and 7 as previously described (Quesseveur et al, 2013). This 7.5 Gy cumulative dose was determined from prior pilot experiments to be the minimum dosage necessary to result in permanent ablation of adult-born neurons in the DG as assessed by expression of the immature neuronal marker DCX.…”
Section: X-irradiationmentioning
confidence: 99%