Bcl1 polymorphism of glucocorticoid receptor gene in patients with bronchial asthma with obesity

Kmyta, V. V.; Garbuzova, Victoria Yu.; Prystupa, Evgen; Prystupa, Liudmyla

doi:10.3103/s0095452716030063

Cited by 8 publications

(13 citation statements)

References 15 publications

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“…The results of the study confirm that the physical rehabilitation trainings using such means as traditional therapeutic gymnastics, a single-step dousing with cold water after a warm shower, morning hygienic gymnastics, autogenic training according to the Schulz technique, have the positive impact on the respiratory system of patients with bronchial asthma Kmyta, 2016).…”

Section: Discussionsupporting

confidence: 59%

“…It was found out that in the young men of the experimental group the whole forty-week period of application of the developed program did not contribute to the improvement of the absolute and relative indices of the aerobic productivity of the organism. In our opinion, the ineffectiveness of the impact of such trainings on the absolute and relative indices of the PWC 170 and VO 2 of the young men of the experimental group is due to the insufficient amount of running loads Kmyta, 2015;Briskin, 2016). According to the calculations, the maximum allowed value of energy consumption (Е mах ) of running loads for one training session was 554.9 kcal for young men, and the minimum (threshold) energy consumption(E min ) was 244.15 kcal, which is 44 % of E max .…”

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confidence: 75%

“…Over the course of the past three decades, medical statistics have documented a steady increase in nonspecific diseases (Herasymenko, 2016;Kmyta, 2015Kmyta, , 2016Lazarieva, 2017). One of them is the respiratory system diseases, which includes bronchial asthma (BA).…”

Section: Introductionmentioning

confidence: 99%

“…Taking into account the fact that the effective application of hypoxia for the prevention and even relief of asthma attacks is described in the special scientific sources, we investigated the rapid effect, that is, the effectiveness of a single application of the endogenous-hypoxic breathing in combination with a metered physical load on a bicycle ergometer with a power of 1W per 1 kg of body weight lasting 5 minutes, on the external respiration indicators of students with this disease Kmyta, 2015;Hruzevych, 2017).…”

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confidence: 99%

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2017

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The article is devoted to the development and evaluation of the effectiveness of the integrated physical rehabilitation program for students suffering from bronchial asthma. For patients with bronchial asthma (BA) it has been developed the integrated physical rehabilitation program, which includes therapeutic physical training (morning hygienic gymnastics, special breathing exercises, metered running and walking on the stadium's running track, action games, relay races, walking and running on stairs and walking through the hurdles), autogenous training, the endogenous-hypoxic breathing technique on the "Endogenic 01" apparatus, single dousing with cold water after a warm shower. It has been proved that its application results in the improvement of the external respiration apparatus function, the physical working capacity and aerobic productivity of the body, increasing the body's ability to adapt to hypoxia conditions, reducing the number of such symptoms of bronchial asthma, as coughing, chest tightness and suffocation.

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Section: Discussionsupporting

confidence: 59%

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confidence: 75%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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2017

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“…One of the reasons for this phenomenon is the improvement of the training process at all stages of the multi-year training of an athlete Viktoriia, 2017;Zhyrnov, 2017). Special attention should be paid to the preparation of athletes in the puberty period of ontogenesis, when cyclists have the stages of preliminary and specialized basic training, since the improvement of physical and functional preparedness in the indicated periods takes place against the backdrop of intense age-related adjustment of the body (Gavrylova, , 2012Kmyta, 2015Kmyta, , 2016Khimenes, 2016;. The enhancement of the efficiency of training sessions by increasing the amount of loads at these stages might not bring the expected increase of sports results, and even can disrupt the balanced activities of those functional systems that are determinants of the process of improving the physical fitness of athletes at the next stages of multi-year training.…”

Section: Introductionmentioning

confidence: 99%

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2017

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The issue of perfection of functional and physical fitness of 13-16 year-old cyclists by means of application of the endogenous-hypoxic breathing techniques in the training process is investigated in the article. Due to the application of the endogenous-hypoxic breathing technique in combination with exercise loads, cyclists aged 13-16 years have positive changes in the apparatus of external respiration: the functional capabilities of the respiratory muscles are increased, the respiratory surface of the lungs increases, there is an economization of the respiratory muscles work in the relative muscular rest state, and it is also facilitated also passage of air in the area of medium and small bronchi is facilitated. The effectiveness of the complex application of normobaric hypoxia and hypercapnia, as well as the training loads on the physical fitness of adolescent cyclists, depends on the age of athletes. In the 13-14-year-old athletes, in 16 weeks after the beginning of the formative experiment, the special physical preparedness increased by the results of the cycling a 200 m flying-start heat (2.75 %, p <0.05) and the cycling a 2,000 m heat with a single turning (by 5.18 %, p <0.01); general physical fitness by results of running 60 m race (by 3,43 %, p <0,05), running a 1,500 m race (3,16 %, p <0,01) and the maximum number of squats in 15 sec (at 8, 57 %, p <0.005). In 15-16-year-old cyclists, training sessions with application of the endogenous-hypoxic breathing technique contributed to an increase in overall physical fitness-according to the results of running a 1,500 m race (2.29 %, p <0.02) and special physical fitness-according to the results of cycling a 2,000 m heat with one turn (5.91 %, p <0.005).

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Association between polymorphisms of glucocorticoid receptor genes and asthma: A meta-analysis

Cai

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Recent studies have evaluated the associations between polymorphisms of glucocorticoid receptor genes and asthma. However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of glucocorticoid receptor genetic loci and susceptibility to asthma, based on existing reports. We conducted a meta-analysis of the association between glucocorticoid receptor polymorphisms (NR3C1) and asthma risk. A systematical literature search was performed in PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library until January 15, 2018. The odds ratio (OR), 95% confidence interval (CI), and P value were calculated using Mantel-Haenszel statistics under the allele, homozygote, heterozygote, dominant, or recessive models. P values of less than 0.05 were considered to represent statistically significant associations between glucocorticoid receptor gene polymorphisms and asthma. All statistical analyses were done using the "meta" package (version 4.9-0) of R version 3.4.3 and RStudio version 1.0.44. A total of fourteen studies, reported via ten articles from online databases were included in our meta-analysis. For BclI (from eight studies), a significant association was detected in the allele model, homozygote model, and recessive model (C versus G: OR (95% CI) = 0.63 (0.40-0.97), CC versus GG: OR (95% CI) = 0.41(0.17-0.97), CC versus GC + GG: OR (95% CI) = 0.54(0.34-0.88)), but not in the heterozygote model or the dominant model. For ER22/23EK (from four studies), TthIII1 (from two studies), no significant association was found for any genetic model. After subgroup analyses by age, significant associations were observed for the allele model, homozygote model, dominant model and recessive model for BclI in adults. The ER22/23EK and TthIII1 polymorphisms were not found to be associated with susceptibility to ASTHMA; however, the BclI polymorphisms were significantly associated with ASTHMA in adults.

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Bcl1 polymorphism of glucocorticoid receptor gene in patients with bronchial asthma with obesity

Cited by 8 publications

References 15 publications

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Association between polymorphisms of glucocorticoid receptor genes and asthma: A meta-analysis

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