2020
DOI: 10.1007/s10495-020-01601-9 View full text |Buy / Rent full text
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Abstract: Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. Deregulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis and have been implicated in colorectal cancer (CRC) initiation, progression and resistance to therapy. In thi… Show more

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