Bcl-2 and Caspase-3 Are Major Regulators in Agaricus blazei-Induced Human Leukemic U937 Cell Apoptosis through Dephoshorylation of Akt

Jin, Cheng‐Yun; Moon, Dong‐Oh; Choi, Yung Hyun; Lee, Jae-Dong; Kim, Gi‐Young

doi:10.1248/bpb.30.1432

Cited by 29 publications

(20 citation statements)

References 24 publications

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“…The result indicated that our extract JAB80E70 inhibited the growth of NB-4 cells, at least in part, by induction of apoptosis. Our finding is consistent with reports from other groups that various extracts from Agaricus blazei induced apoptosis in various human leukemia cells, such as Jurkat, BALL-1 and U937 (Jin et al, 2007;Kawamura and Kasai, 2007).…”

Section: Discussionsupporting

confidence: 93%

“…Mechanistics studies have demonstrated that the anti-tumor activities of Agaricus blazei extracts can be related to induction of apoptosis, cell-cycle arrest, inhibition of tumor-induced neovascularization, immunopotentiation and restoration of tumor-suppressed host immune system Fujimiya et al, 1998;Kimura, 2005;Kimura et al, 2004;Kobayashi et al, 2005). Despite these findings, very few studies on the inhibitory effects of Agaricus blazei extracts on human leukemic cells have been reported (Jin et al, 2007;Kawamura and Kasai, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory effects of Agaricus blazei extracts on human myeloid leukemia cells

Kim

Jiang

Leung

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Agaricus blazei extracts on human myeloid leukemia cells

Kim

Jiang

Leung

et al. 2009

Journal of Ethnopharmacology

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“…Recently, extracts of propolis were shown to trigger various apoptotic pathway in different types of cancer cells [24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Elementery Analysis and anti-Tumor Activity on Glioblastoma Cell Lines of Propolis Samples from Giresun Province of Turkey

Atabay¹,

Sezgın²,

Taşpınar³

et al. 2017

UCMS

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Abstract:One of the natural products which have been used as a folk medicine is propolis. It is reported to exhibit several biological activities. Trace and macro-element profiles in propolis provided information enough to develop the classification of the geological origin of propolis. The geological origin of propolis determines its biological properties. It has become a promising anticancer natural agent in the recent days. The first purpose of this study was to determine macro-element and heavy metal contents of raw propolis samples originating from Giresun, a rainy and temperate region of Turkey. The second purpose of this study was to assess cell viability on glioblastoma cell lines of propolis samples. Macro-element and heavy metal contents (Mg, Na, Al, Si, K, Fe, Cu, Zn, Mn) of raw propolis samples from Giresun, were evaluated using inductively coupled plasma spectrometer with mass detection. Glioblastoma cell lines were exposed to different concentrations of propolis, and the apoptotic levels were determined using apoptosis assay. Additional cell viability and proliferation were analyzed by XXT assay. We used the XTT assay to assess cellular proliferation and viability. Turkish propolis is rich in the minerals. Potasium content was at a relatively higher level than other elements in samples from various regions of Turkey. The results obtained indicate no pollution of the collection areas. Results showed that apoptotic cell population increased significantly in glioblastoma cell lines exposed to increasing concentrations of propolis extracts. We reported the antiproliferative activity of these propolis on cancer cells. We suggested the induction of apoptosis after treatment with Turkish propolis on glioblastoma cell lines. Further studies are needed to advance in the understanding of the molecular basis of apoptosis induction on by Turkish propolis.

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“…blazei (Gao et al, 2007), Hypsizigus marmoreus (Mizumoto et al, 2008) and other mushrooms have been shown to inhibit cell proliferation of HL-60 leukemia cells and other leukemia human cell lines via the induction of apoptosis. Mechanisms by which apoptosis is induced include down-regulation of telomerase activity and up-regulation of mRNA expression of the caspase-3 gene (Gao et al, 2007), regulation of Bcl-2 and caspase-3 (Jin, Moon, Choi, Lee, & Kim, 2007), cleavage of poly (ADP-ribose) polymerase and pro-caspase 3 (Bae et al, 2009), mitochondrial membrane potential loss and caspase activation (Mizumoto et al, 2008), release of mitochondrial cytochrome c and subsequent activation of caspase-9 and caspase-3 (Hsu, Yu, & Yen, 2008b) and via the signal transduction kinases Akt and Erk (Calvino et al, 2010). These extracts appear to exert tumor-selective cytotoxicity, with studies reporting no significant cytotoxic effects on normal cell lines (Lau et al, 2004).…”

Section: Leukemiamentioning

confidence: 99%