BCA-1, A B-cell chemoattractant signal, is constantly expressed in cutaneous lymphoproliferative B-cell disorders

Abstract

We analysed the immunophenotypic and molecular expression of BCA-1 (B-cell-specific chemokine) and CXCR5 (BCA-1 receptor) in normal skin and different cutaneous lymphoproliferative disorders (cutaneous T-cell lymphoma (CTCL); cutaneous B-cell lymphoma (CBCL); cutaneous B-cell pseudolymphoma (PCBCL)), with the aim of investigating their possible involvement in the pathogenesis of cutaneous B-cell disorders. BCA-1 and CXCR5 were constantly expressed in CBCL and PCBCL, but not in normal skin and CTCL. BCA-1 and CXCR5 were constantly coexpressed by CD22+ B-cells, while CD35+ follicular dendritic cells coexpressed BCA-1 in PCBCL cells only. In low grade CBCL, as compared with high grade CBCL, the intensity of CXCR5 expression on neoplastic CD22+ cells was lower than that of BCA-1. The image analysis of reverse transcriptase-polymerase chain reaction (RT-PCR) products showed a significant quantitative difference between PCBCL/low grade CBCL and high grade CBCL. The above findings, although only observed in a small series of patients, are in keeping with findings in MALT gastric and gastric MALT lymphomas, adding further evidence of the close similarities between CBCL and MALT lymphomas. #

Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis

“…No previous information is available concerning the expression of this molecule in the skin of these patients. At variance from cutaneous lymphoproliferative B-cell disorders, in which CXCL13 was detected as a cellassociated molecule constantly expressed by neoplastic B cells and follicular dendritic cells within lymphoid infiltrates, 42 we established a staining pattern consisting of a diffuse expression of CXCL13 protein in the dermis along collagen bundles. This feature, with variable expression in the different areas of the dermis, paralleled the expression of specific mRNA signal, suggesting that CXCL13 is dependent on up-regulation of CXCL13-producing cells.…”

Lymphoma dissemination: the other face of lymphocyte homing

“…on May 10, 2018. by guest www.bloodjournal.org From stimulation, in the skin or at other extralymphoid sites such as the stomach mucosa or the orbit, B-cell lymphomas, in particular marginal zone and follicular lymphomas, can eventually arise. [72][73][74] Naive B cells need to recirculate freely through peripheral and mucosal lymphoid tissues to optimize their chances of meeting their cognate antigen, whereas B memory cells and plasmablasts have to migrate to specific lymphoid environments dedicated to their recall and effector functions. Like T cells, B cells consequently must adapt their homing signature to their specific maturational stage (Figure 4).…”

Peripheral T-cell Lymphoma With Follicular T-cell Markers

“…Nevertheless, the expression of none of these markers is specific to AITL as there are reported cases of the expression of PD-1 in adult T-cell leukemia/lymphoma, 61 and of CXCL13 in primary central nervous system lymphoma, 63 mucosa-associated lymphoid tissue gastric lymphomas, 43 and in all cutaneous lymphoproliferative B-cell disorders. 45 Furthermore, it is well known that BCL6 is expressed in many different subtypes of B-cell and T-cell leukemic/lymphoid neoplasms. 35 We investigated CD10 expression in this study because it is also expressed in the neoplastic component of AITL.…”