2001
DOI: 10.1186/1472-6793-1-8 View full text |Buy / Rent full text
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Abstract: Background: The multisubunit (α 1S ,α 2 -δ, β 1a and γ 1 ) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca 2+ from the sarcoplasmic reticulum (SR) and also acts as an L-type Ca 2+ channel. To more fully investigate the function of the γ 1 subunit in these two processes, we produced mice lacking this subunit by gene targeting.

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