Journal of the American Statistical Association volume 104, issue 485, P132-141 2009 DOI: 10.1198/jasa.2009.0009 View full text
Paul Fearnhead, Despina Vasileiou

Abstract: The statistical identification of isochore structure, the variation in large scale GC composition, of mammalian genomes is a necessary requirement for understanding both the evolution of base composition and the many genomic features such as mutation and recombination rates which covary with base composition. We have developed a Bayesian method for isochore analysis, which we demonstrate to be more accurate than the commonly used binary segmentation approach implemented within the program IsoFinder. The method…

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