Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Jandl, Katharina; Berg, Johannes Lorenz; Birnhuber, Anna; Fließer, Elisabeth; Borek, Izabela; Seeliger, Benjamin; David, Sascha; Schmidt, Julius J.; Gorkiewicz, Gregor; Zacharias, Martin; Welte, Tobias; Olschewski, Horst; Heinemann, Ákos; Wygrecka, Małgorzata; Kwapiszewska, Grażyna

doi:10.3389/fimmu.2023.1188079

Cited by 5 publications

(1 citation statement)

References 53 publications

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“…W. Kübler (Berlin, Germany) presented advances in the understanding of tissue barrier dysfunction in pathogen-associated respiratory failure. It has been found that the matrikine endostatin is increased in the lungs of patients with acute respiratory distress syndrome (ARDS), including COVID-19-related ARDS, and this increase promotes thrombin-induced epithelial barrier dysfunction and platelet and neutrophil activation [ 45 ]. Loss of the endothelial aryl hydrocarbon receptor (AHR) also increases tissue barrier dysfunction and subsequent movement of inflammatory cells into alveoli following influenza infection.…”

Section: Scientific Year In Reviewmentioning

confidence: 99%

ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

Reddy,

Bizymi,

Schweikert

et al. 2023

ERJ Open Res

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In this article, early career members of the Assembly 3: Basic and Translational Sciences of the European Respiratory Society summarise the key messages discussed during six selected sessions that took place at the ERS congress 2023 in Milan, Italy. Aligned with the theme of the congress, the first topic covered is “micro- and macro-environments and respiratory health”, followed by a summary of the “Scientific year in review” session. Next, recent advances in experimental methodologies and new technologies were highlighted within the “tissue modelling and remodelling” session, as well as summary of the translational science session, “what did you always want to know about omics analyses for clinical practice?”, organised as part of the ERS Translational Science Working group's aims. Details on how the next-generation sequencing can be integrated with laboratory methods were provided in the “lost in translation: new insights into cell-to-cell crosstalk in lung disease” session and a final summary of studies presented in the “from the transcriptome landscape to innovative preclinical models in lung diseases” session linking the transcriptome landscape with innovative preclinical models was included in this review. The wide range of topics covered in the selected sessions and the high quality of the research discussed highlight the strength of the basic and translational science being presented at the international respiratory conference organised by the ERS.

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Section: Scientific Year In Reviewmentioning

confidence: 99%

ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

Reddy,

Bizymi,

Schweikert

et al. 2023

ERJ Open Res

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Matrikines in the skin: Origin, effects, and therapeutic potential

Sirois,

Heinz

2024

Pharmacology & Therapeutics

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Plasma endostatin is an early creatinine independent predictor of acute kidney injury and need for renal replacement therapy in critical care

Koozi,

Engström,

Spångfors

et al. 2024

Preprint

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Purpose:Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin upon ICU admission as a predictor of AKI, renal replacement therapy (RRT), and 30-day mortality.Methods:A retrospective multicenter study was performed with admissions (ICU length of stay ≥24 hours) to four ICUs. KDIGO criteria defined AKI. Endostatin on ICU admission was compared to creatinine, cystatin C, and the Simplified Acute Physiology Score 3 (SAPS-3). Admissions with sepsis and creatinine <100 μmol/L on ICU admission underwent subgroup analyses. Regression models and the area under the receiver operating characteristic curve (AUC) were assessed.Results:In total, 4449 admissions were included (43% sepsis and 61% AKI). Endostatin was associated with AKI (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.4-1.7), future AKI (OR 1.5, 95% CI 1.4-1.7), future AKI stage 3 (OR 1.4, 95% CI 1.2-1.6), and RRT (OR 1.2, 95% CI 1.1-1.4) independently of creatinine and cystatin C, with similar results in sepsis. Endostatin was also associated with time to AKI (hazard ratio 1.2, 95% CI 1.1-1.2). For admissions with creatinine <100 μmol/L, endostatin (AUC 0.62, 95% CI 0.59-0.65) outperformed creatinine (AUC 0.51, 95% CI 0.49-0.54) and cystatin C (AUC 0.53, 95% CI 0.50-0.56) in predicting future AKI (p<0.001). Endostatin was not associated with 30-day mortality after adjusting for SAPS-3.Conclusion:Endostatin is an early and potentially clinically useful biomarker for predicting AKI and RRT needs at ICU admission, especially in patients with low to mildly elevated creatinine.

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Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Cited by 5 publications

References 53 publications

ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

Matrikines in the skin: Origin, effects, and therapeutic potential

Plasma endostatin is an early creatinine independent predictor of acute kidney injury and need for renal replacement therapy in critical care

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