Baseline extracellular potassium level as an indicator of the rate of increase of the same on further storage in <scp>CPDA</scp>‐1 whole blood units: a potential approach to complement <scp>FIFO</scp> system for prioritisation of blood bags for release from blood‐banks

Baliarsingh, S.; Jaiswal, Milan

doi:10.1111/tme.12086

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…The supernatant potassium concentration increased immediately after irradiation and was significantly higher than controls after only 2 h. The increase in supernatant potassium in irradiated RCCs was linear over the first 24 h of storage ( R 2 = 0·998 for paediatric and R 2 = 0·996 for full‐size RCCs). Other studies have also reported a time‐dependent correlation with increasing potassium concentrations . The results from this study demonstrate that the increase in supernatant potassium following irradiation between the full‐size and paediatric packs was equivalent, suggesting that red cell membrane damage was not elevated in the smaller packs.…”

Section: Discussionsupporting

confidence: 61%

Understanding the effects of gamma‐irradiation on potassium levels in red cell concentrates stored in SAG‐M for neonatal red cell transfusion

et al. 2014

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Section: Discussionsupporting

confidence: 61%

Understanding the effects of gamma‐irradiation on potassium levels in red cell concentrates stored in SAG‐M for neonatal red cell transfusion

et al. 2014

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“…In a recent study conducted in a Tertiary care hospital in Uttar Pradesh by Baliar S. and Jaiswal M., who studied CPDA-1 blood bags over a period of 28 days the following conclusions were drawn (i) low baseline potassium blood bags might be preferred for transfusion in cases demanding a low potassium load and (ii) coordinating the 'first-in-first-out' (FIFO) policy with 'early release of blood-bags with high initial potassium' might be helpful in improving the release of suitable blood units from blood-banks. 34 The association between transfusion of stored blood units having high K levels and cardiac dysfunction has been well demonstrated 18,19,35 . We attempt to study possible relationships between K concentrations and levels of some commonly used laboratory parameters in CPDA-1 blood bags and SAGM bags by serially examining them.…”

Section: E) Arrival Of the "Omics Generation"mentioning

confidence: 99%

“…The response of WBCs from transfusion recipients with co-existing morbidities that modulate their immune and/or coagulation or vascular systems is not known and adds further dimensions to the complexity of the potential effects of Transfusion Related Immunomodulation. [34][35][36] Hemolysis during processing can occur due to various reasons. Delay between collection and processing, rapid anticoagulation, high centrifugation speed, rapid addition of additive solution to packed red cells and variation in the quality of blood storage bags all contribute to hemolysis.…”

Section: E) Arrival Of the "Omics Generation"mentioning

confidence: 99%

Assessment of Storage Related Haematological and Biochemical Changes in Blood Units

Kaur¹

2021

GJMR

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Red blood cells are still the most widely transfused blood component worldwide and their story is intimately entwined with the history of transfusion medicine and the changes in the collection and storage of blood.1,2 At present, the most widely used protocol for the storage of red blood cells (for up to 42 days) is the collection of blood into anticoagulant solutions (typically citrate-dextrose-phosphate); red cell concentrates are prepared by the removal of plasma and, in some cases, also leukoreduction. The product is stored at 4 ± 2° C in a slightly hypertonic additive solution, generally SAGM (sodium, adenine, glucose, mannitol, 376 mOsm/L).1 The British obstetrician, Braxton Hicks in 1868, experimented with a solution of phosphate of soda, but this also proved toxic. Richard Lewinsohn, in 1915, of the Mount Sinai Hospital in New York is credited with introducing sodium citrate into clinical practice as an anticoagulant.3In fact, a 1% solution of sodium citrate was already widely used in laboratories as an anticoagulant. This high concentration was toxic to humans but, as Lewinsohn himself recalled, `Nobody had ever followed the simple thought of carrying out experiments to ascertain whether a much smaller dose might not be sufficient' for use as an anticoagulant.

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“…The extracellular K + level increases with the duration of red blood cell (RBC) storage . Furthermore, the K + level in the supernatant of stored packed RBCs increases rapidly and exceeds 50 mEq/L within 1 week after irradiation .…”

mentioning

confidence: 99%

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Suzuki¹,

Muto

Miyata

et al. 2015

Ther Apher Dial

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A K(+) -adsorption filter was developed to exchange K(+) in the supernatant of stored irradiated red blood cells with Na(+) . To date, however, the filter's adsorption capacity for K(+) has not been fully evaluated. Therefore, we characterized the cation-binding capacity of this filter. Artificial solutions containing various cations were continuously passed through the filter in 30 mL of sodium polystyrene sulfonate at 10 mL/min using an infusion pump at room temperature. The cation concentrations were measured before and during filtration. When a single solution containing K(+) , Li(+) , H(+) , Mg(2+) , Ca(2+) , or Al(3+) was continuously passed through the filter, the filter adsorbed K(+) and the other cations in exchange for Na(+) in direct proportion to the valence number. The order of affinity for cation adsorption to the filter was Ca(2+) >Mg(2+) >K(+) >H(+) >Li(+) . In K(+) -saturated conditions, the filter also adsorbed Na(+) . After complete adsorption of these cations on the filter, their concentration in the effluent increased in a sigmoidal manner over time. Cations that were bound to the filter were released if a second cation was passed through the filter, despite the different affinities of the two cations. The ability of the filter to bind cations, especially K(+) , should be helpful when it is used for red blood cell transfusion at the bedside. The filter may also be useful to gain a better understanding of the pharmacological properties of sodium polystyrene sulfonate.

show abstract

Baseline extracellular potassium level as an indicator of the rate of increase of the same on further storage in CPDA‐1 whole blood units: a potential approach to complement FIFO system for prioritisation of blood bags for release from blood‐banks

Cited by 3 publications

References 18 publications

Understanding the effects of gamma‐irradiation on potassium levels in red cell concentrates stored in SAG‐M for neonatal red cell transfusion

Understanding the effects of gamma‐irradiation on potassium levels in red cell concentrates stored in SAG‐M for neonatal red cell transfusion

Assessment of Storage Related Haematological and Biochemical Changes in Blood Units

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

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