Baseline-dependent modulating effects of nicotine on voluntary and involuntary attention measured with brain event-related P3 potentials

Knott, Verner; Choueiry, Joëlle; Dort, H.; Smith, Dylan M.; Impey, Danielle; Philippe, Tristan

doi:10.1016/j.pbb.2014.03.020

Cited by 33 publications

(29 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nicotine administration enhances ERP indices of both top down and bottom up attention and cholinergic mediated decorrelation of neuronal activity in V1 increases response reliability of neurons under both goal oriented, trained paradigms as well as during observation of naturalistic movies (Goard and Dan, 2009; Knott et al, 2014; Pinto et al, 2013). Enhancing cholinergic tone may therefore increase signal to noise ratios and facilitate stimulus detection whether or not performance is goal-oriented.…”

Section: Cholinergic Signaling and Circuits Involved In Attention mentioning

confidence: 99%

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Ballinger

Ananth

Talmage

et al. 2016

Neuron

576

517

View full text Add to dashboard Cite

Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning, and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.

show abstract

Section: Cholinergic Signaling and Circuits Involved In Attention mentioning

confidence: 99%

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Ballinger

Ananth

Talmage

et al. 2016

Neuron

576

517

View full text Add to dashboard Cite

show abstract

“…Recent evidence also indicates that transdermal nicotine can increase sustained attention in adult nonsmokers with poorer attentiveness, but negatively impacts participants higher in attentiveness (Poltavski and Petros, 2006). In nonsmokers, findings by Knott et al (2014) generally support baseline-dependent nicotine effects on both voluntary and involuntary neural aspects of attention as measured by ERPs. Such findings in nonsmokers suggest baseline-dependent nicotine effects separate from mere withdrawal alleviation, in support of Perkins’ (1999) model.…”

Section: Discussionmentioning

confidence: 52%

“…Consistent with baseline-dependency, Patterson et al (2010) recently found that poorer working memory on a rapid information processing task (the N-Back) during nicotine abstinence predicted more rapid resumption of smoking in individuals attempting smoking cessation. Baseline-dependent effects of nicotine have also been observed for P3 event-related potential amplitudes during involuntary novel auditory processing in nonsmokers, demonstrating increased attentional enhancement by nicotine only in individuals with relatively poor attentional capacity (Knott et al 2014). We are not aware of studies assessing the influence of existing placebo-baseline deficits on covert spatial attention enhancement by nicotine in smokers.…”

Section: Introductionmentioning

confidence: 94%

Moderation of nicotine effects on covert orienting of attention tasks by poor placebo performance and cue validity

Hammersley

Gilbert

Rzetelny

2016

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Introduction and Rationale Given baseline-dependent effects of nicotine on other forms of attention, there is reason to believe that inconsistent findings for the effects of nicotine on attentional orienting may be partly due to individual differences in baseline (abstinence state) functioning. Individuals with low baseline attention may benefit more from nicotine replacement. Method The effects of nicotine as a function of baseline performance (bottom, middle, and top third of mean reaction times during placebo) were assessed in 52 habitual abstinent smokers (26 females/26 males) utilizing an arrow-cued covert orienting of attention task. Results Compared to a placebo patch, a 14 mg nicotine patch produced faster overall reaction times (RTs). In addition, individuals with slower RTs during the placebo condition benefitted more from nicotine on cued trials than did those who had shorter (faster) RTs during placebo. Nicotine also enhanced the validity effect (shorter RTs to validly vs. invalidly cued targets), but this nicotine benefit did not differ as a function of overall placebo-baseline performance. Conclusions These findings support the view that nicotine enhances cued spatial attentional orienting in individuals who have slower RTs during placebo (nicotine-free) conditions; however, baseline-dependent effects may not generalize to all aspects of spatial attention. These findings are consistent with findings indicating that nicotine’s effects vary as a function of task parameters rather than simple RT speeding or cognitive enhancement.

show abstract

“…Previous work has shown that the P3b is enhanced following nicotine and tobacco use. 23,24 Although the P3b was not significantly influenced by product type, this may reflect the relatively smaller sample size of the present investigation. Previous work has also generally demonstrated modulation of the N2 in response to nicotine and tobacco use, although the results have been mixed (for a review see: Pritchard et al 22 ).…”

Section: Discussionmentioning

confidence: 66%

“…In line with this notion, previous research has shown that traditional cigarettes, or nicotine alone, can enhance alpha suppression, 18-21 N2, 22 and P3b amplitude. [22][23][24] EEG and ERPs have previously been used as a way to assess the effect of tobacco or nicotine on attention and brain state arousal. 18,23,[25][26][27][28][29][30] However, to our knowledge, this is the first study employing EEG in conjunction with traditional subjective measures of consumer acceptability in order to compare a variety of smokeless tobacco products.…”

Section: Introductionmentioning

confidence: 99%

Using Electrophysiological Measures to Assess the Consumer Acceptability of Smokeless Tobacco Products

Buzzell

Das

Cruz‐Cano

et al. 2016

NICTOB

View full text Add to dashboard Cite

Introduction: Adequate evaluation of novel tobacco products must include investigation of consumers' psychological response to such products. Traditionally, subjective scales of product liking have been used to assess consumer acceptability of tobacco products. However, subjective scales may miss cognitive changes that can only be captured by direct neurophysiological assessment. The present investigation explored the viability of using electroencephalography (EEG), in combination with traditional subjective measures, to assess consumer acceptability of five smokeless tobacco products. Given previous work linking product liking to arousal/attentional (executive function) enhancement, we focused on EEG measures of attention/arousal to objectively characterize cognitive changes associated with tobacco product use. Methods: During five separate laboratory visits, smokeless tobacco users used Verve discs, Ariva dissolvables, Skoal snuff, Camel snus, or Nicorette lozenges. The N2 and P3b event-related potential components elicited by an oddball task were used to index attentional changes before/after product usage. Additionally, resting state alpha band EEG activity was analyzed before/after product usage to index cortical arousal. Results: Although analyses of the subjective results provided limited inference, analyses of the electrophysiological measures, particularly the alpha suppression measure, revealed robust differences between products. Skoal elicited significantly enhanced alpha suppression compared to all four other products tested. Additionally, alpha suppression was found to correlate positively with subjective measures of satisfaction and psychological reward, but was unrelated to perceived aversion. Conclusions:The present results provide evidence that electrophysiological measures can yield important insights into consumer acceptability of novel tobacco products and are a valuable complement to subjective measures. Implications: This study is the first to employ a combination of electrophysiological measures and traditional subjective assays in order to assess the consumer acceptability of smokeless tobacco products. The results highlight the importance of adopting a multidimensional/multi-method approach to studying the consumer acceptability of tobacco products.

show abstract

Baseline-dependent modulating effects of nicotine on voluntary and involuntary attention measured with brain event-related P3 potentials

Cited by 33 publications

References 96 publications

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Moderation of nicotine effects on covert orienting of attention tasks by poor placebo performance and cue validity

Using Electrophysiological Measures to Assess the Consumer Acceptability of Smokeless Tobacco Products

Contact Info

Product

Resources

About