Base-promoted cyclization reaction of o-isothiocyanato arylacetylenes and aroylacetonitriles: easy access to benzo[d][1,3]thiazines

Abstract

A green and efficient synthesis of benzo[d][1,3]thiazines through base-promoted cyclization reaction of o-isothiocyanato arylacetylenes with aroylacetonitriles has been developed. This protocol displays high step economy and efficiency, and tolerates various...

Isothiocyanates: happy-go-lucky reagents in organic synthesis

“…The synthetic utility of this methodology was demonstrated by late-stage functionalization of clinical drugs such as tofacitinib (Scheme 46). 56…”