Base‐Mediated Defluorosilylation of C(sp²)−F and C(sp³)−F Bonds

Abstract

The ability to selectively forge C–heteroatom bonds by C−F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base‐mediated defluorosilylation of unactivated C(sp2)−F and C(sp3)−F bonds that obviates the need for metal catalysts. This protocol is characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late‐stage functionalization, constituting a complementary approach to existing C−Si bond‐forming protocols.

Amino Acids and Peptide‐Based Supramolecular Hydrogels for Three‐Dimensional Cell Culture

“…More than this, the chiral twist with right-handed and lefthanded enantiomers was also obtained by incorporating chiral center into C 2 based hydrogelators. [63] By the method above, well-controlled chiral nanofibers could be obtained (Figure 8b). It is known that chirality is one of the most distinctive signatures of life and has great influence on many biological events.…”

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“…In Hammett‐Studien wurde ein ρ ‐Wert von +3.2 gefunden, und quantenchemische Untersuchungen ergaben eine Gibbs‐Aktivierungsenergien von 19–21 kcal mol −1 (Schema ). Vor kurzem sind auch zwei verwandte Studien aus anderen Forschungsgruppen erschienen …”

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