volume 285, issue 37, P28683-28690 2010
DOI: 10.1074/jbc.m110.113530
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Abstract: DNA repair takes place in the context of chromatin. Previous studies showed that histones impair base excision repair (BER) of modified bases at both the excision and synthesis steps. We examined BER of uracil in a glucocorticoid response element (GRE) complexed with the glucocorticoid receptor DNA binding domain (GR-DBD). Five substrates were designed, each containing a unique C→U substitution within the mouse mammary tumor virus promoter, one located within each GRE half-site and the others located outside t…

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