Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression

Faron-Górecka, Agata; Kuśmider, Maciej; Szafran-Pilch, Kinga; Kolasa, Magdalena; Żurawek, Dariusz; Gruca, Piotr; Papp, Mariusz; Solich, Joanna; Pabian, Paulina; Dziedzicka-Wasylewska, Marta

doi:10.1016/j.neulet.2017.03.034

Cited by 10 publications

(5 citation statements)

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“…The involvement of neuropeptides in mental disorders and in the mechanism of action of drugs has been postulated. In our previously published studies, we have demonstrated a significant negative correlation between basal prolactin levels (i.e., before the CMS procedure) and the behavioural response to IMI administration (Faron-Górecka et al 2017). Recently, we also highlighted the role of sst 2 R in the stress reaction (Faron-Górecka et al 2016; Faron-Górecka & Szafran-Pilch 2016).…”

Section: Discussionmentioning

confidence: 69%

“…Additionally, this model allowed for the identification of the animals who did not respond behaviourally to antidepressant treatment (IMI-NR). The percentage of animals that is IMI-NR is usually approximately 30% of the tested animals (Faron-Górecka et al 2014; Żurawek et al 2015; Faron-Górecka et al 2017). This result highlights an advantage of this animal model of depression (for review: Willner 2016), which is the expression of a treatment-resistant model of depression, as is frequently encountered in patients in the clinic.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

et al. 2018

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RationaleThe role of somatostatin and its receptors for the stress-related neuropsychiatric disorders has been widely raised. Recently, we have also demonstrated the involvement of somatostatin receptor type 2-sst2R and dopamine receptor type 2-D2R in stress.ObjectiveIn this context, we decided to find if these receptors are involved in response to antidepressant treatment in animal model of depression—chronic mild stress (CMS).MethodsHere, we report data obtained following 7-week CMS procedure. The specific binding of [125I]Tyr3-Octreotide to sst2R and [3H]Domperidone to D2R was measured in the rat brain, using autoradiography. Additionally, the level of dopamine and metabolites was measured in the rat brain.ResultsIn the final baseline test after 7 weeks of stress, the reduced consumption of sucrose solution was observed (controls vs the stressed animals (6.25 0.16 vs. 10.39 0.41; p < 0.05). Imipramine was administered for the next 5 weeks, and it reversed anhedonia in majority of animals (imipramine-reactive); however, in some animals, it did not (imipramine-non-reactive). Two-way repeated measures ANOVA revealed significant effects of stress and treatment and time interaction [F(16, 168) = 3.72; p < 0.0001], n = 10 per groups. We observed decreased binding of [125I]Tyr3-Octreotide in most of rat brain regions in imipramine non-reactive groups of animals. The decrease of D2R after stress in striatum and nucleus accumbens and no effect of imipramine were observed.In the striatum and prefrontal cortex, the significant role of stress and imipramine in dopamine levels was observed.ConclusionsThe results obtained in binding assays, together with dopamine level, indicate the involvement of sst2R receptors for reaction to antidepressant treatment. Besides, the stress context itself changes the effect of antidepressant drug.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

et al. 2018

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“…In contrast, the sexually dimorphic expression of ERα and GPER in the pituitary could be at the base of the sex differences in the stress response and stress-related diseases. Indeed, ERα is critical for PRL function that has been demonstrated to have a modulatory effect on reactivity to stress response and antidepressant treatment with increased PRL levels reported in a stress-resilience male rat phenotype (Faron-Gorecka et al, 2014 ) and decreased basal PRL plasma levels correlated with decreased responsiveness to antidepressant treatment (Faron-Gorecka et al, 2017 ). In addition, ovariectomy increased the GPER expression in lactotropic cells and GPER agonist treatment stimulated PRL secretion in female rats (Camilletti et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats

et al. 2022

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Sex steroid hormones, such as androgens and estrogens, are known to exert organizational action at perinatal periods and activational effects during adulthood on the brain and peripheral tissues. These organizational effects are essential for the establishment of biological axes responsible for regulating behaviors, such as reproduction, stress, and emotional responses. Estradiol (E2), testosterone, and their metabolites exert their biological action through genomic and non-genomic mechanisms, bounding to canonical receptors, such as estrogen receptor (ER)α, ERβ, and androgen receptor (AR) or membrane receptors, such as the G protein-coupled estrogen receptor (GPER), respectively. Expression of ERs and AR was found to be different between males and females both in the brain and peripheral tissues, suggesting a sex-dependent regulation of their expression and function. Therefore, studying the ERs and AR distribution and expression levels is key to understand the central and peripheral role of sex steroids in the establishment of sex-specific behaviors in males and females. We investigated the organizational effects of estrogens and androgens in the pituitary and adrenal glands of adult male and female rats. For this, selective blockade of AR with flutamide or 5α-reductase with finasteride or aromatase with letrozole during the first 5 days of life has been performed in male and female pups and then quantification of ERs and AR expression in both glands has been carried out in adulthood. Data show that inhibition of dihydrotestosterone (DHT) and E2 production during the first five postnatal days mainly decreases the ER expression in male to female values and AR expression in female to male levels in the pituitary gland and increases AR expression in female to male levels in the adrenal gland. In contrast, blocking the action of androgens differentially modulates the ERs in males and females and decreases AR in both males and females in both glands. Altogether, the results suggest that neonatal modifications of the androgen and estrogen pathways can potentially lead to permanent modifications of the neuroendocrine functions of the pituitary and adrenal glands in the adulthood of both sexes.

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“…This drug inhibits not only the reuptake of serotonin, but also norepinephrine and dopamine; therefore, it is reasonable to suppose that the dopaminergic system may also play a significant role in these phenomena. The observed negative correlation between baseline PRL levels and responses to drug administration in the CMS model suggests that PRL may predict responses to the pharmacotherapy of depression [ 35 ]. This hypothesis is confirmed by the observation that in patients with major depression, after electroconvulsive therapy, pharmacotherapy, and psychotherapy, high PRF (prolactin secretion responses to fenfluramine) was positively correlated with responses to treatment [ 36 ].…”

Section: Prl and Neuropsychiatric Disordersmentioning

confidence: 99%

The Involvement of Prolactin in Stress-Related Disorders

Faron-Górecka

Latocha

Pabian

et al. 2023

IJERPH

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The most important and widely studied role of prolactin (PRL) is its modulation of stress responses during pregnancy and lactation. PRL acts as a neuropeptide to support physiological reproductive responses. The effects of PRL on the nervous system contribute to a wide range of changes in the female brain during pregnancy and the inhibition of the hypothalamic–pituitary axis. All these changes contribute to the behavioral and physiological adaptations of a young mother to enable reproductive success. PRL-driven brain adaptations are also crucial for regulating maternal emotionality and well-being. Hyperprolactinemia (elevated PRL levels) is a natural and beneficial phenomenon during pregnancy and lactation. However, in other situations, it is often associated with serious endocrine disorders, such as ovulation suppression, which results in a lack of offspring. This introductory example shows how complex this hormone is. In this review, we focus on the different roles of PRL in the body and emphasize the results obtained from animal models of neuropsychiatric disorders.

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Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression

Cited by 10 publications

References 24 publications

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat

Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats

The Involvement of Prolactin in Stress-Related Disorders

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