Basal-Cell Epitheliomas of the Sole

Eccrine Poroma

“…In the original report, for example, it was emphasized th at melanin was not seen, th a t tonofibrils were absent, keratin cysts were rare, and th a t the tum or cells consistently dem onstrated glycogen. Subsequently melanin has been noted in Negro [17] and Japanese [27] patients, tonofibrils have been seen [27], and keratin cysts have been observed by other authors [9,11,22,28] as well as in one case of the present series. A bundant glycogen has been noted in most tum ors, but its distribution and intensity have varied.…”

“…It apparently never struck previous observers th at seborrheic keratosis is not found on plantar skin, which is by far the commonest site for eccrine poroma. In a previous communication [16] it was concluded th at two cases of basal cell epithelioma of the sole reported by Zugerman [28] were in reality eccrine poromas, and th at a tum or of the sole considered by Hunter and Hellier [15] to be an eccrine poroma was actually a basal cell epithelioma. In one of our patients a " cystic" nodule had been removed from the knee.…”

Basal Cell Carcinoma of the Sole

“…Basal cell carcinoma (BCC) strictly limited to the sole is very rare in the dermatologic literature; fewer than 30 cases have been described (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Most cases have been female patients within a range from 35 to 92 years.…”

Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update

“…The use of the term ‘eccrine poroma’ spread considerably after its first description in 1956 by Pinkus et al ., 22 who reported ‘five tumors thought to be related to the eccrine sweat pore in as much as they have histologic features of the intraepidermal part of the sweat duct’. The other terms were introduced later by Smith and Coburn, Winkelman and McLeod and Abenoza and Ackerman, respectively 22–25 . In parallel, poroid tumours with apocrine, sebaceous and follicular differentiation have also been reported, and some authors have considered them as variants of poroma with aberrant differentiation while others have suggested that they belong to a distinct group of adnexal tumours referred to as ‘apocrine’ or ‘holocrine poroma’ 1,2,26 …”