Basal cell epithelioma in a BCG vaccination scar

Basal Cell Carcinoma Arising within a Bacillus Calmette-Guerin Scar: Case Report and Literature Review

“…The second patient was a 36-year-old housewife, who noticed a small, hyperkeratotic lesion at the site of the scar 12.5 years after BCG vaccination ( 7 ). Similarly, Nielson et al ( 8 ), in 1979, described a 52-year-old Norwegian woman with a positive history of superficial melanoma. At the injection site, examination revealed a 12×15 mm, sharply delimited, eczematous, infiltrative lesion.…”

“…At the injection site, examination revealed a 12×15 mm, sharply delimited, eczematous, infiltrative lesion. She was diagnosed with BCC approximately 10 years after vaccination ( 8 ). In 1992, Braithwaite et al ( 9 ) reported a particularly rare case of a woman who, at the very young age of 25 years, noticed that a vaccine scar had become larger, red and scaly.…”

Juvenile Melanoma after BCG Vaccination

“…Keloid, epithelial cysts and granuloma have been described [Watkins, 1971] and recently a basal cell epithelioma [Nielsen, 1979], Lokich [1975] re ported the development of a malignant melanoma 4 weeks after a BCG scarification in a patient with multiple melanomas. In this last case, however, no inflammatory cells were observed, although skin test with BCG showed the same positive responses as the pretherapy tests.…”

Trauma as a Possible Etiologic Factor in Basal Cell Carcinoma

“…Numerous types of trauma have been identified in connection with subsequent basal cell carcinoma formation. These include thermal burn scars, 4–13 vaccination sites, 14–25 chicken pox scars, 26 tattoos, 27 sites of blunt or sharp injury, 9,10,28–30 skin exposed to polycyclic aromatic hydrocarbons, 31 scars of lupus vulgaris, 32 chronic stasis ulcers, 33 sites of frostbite, 34 a hair transplantation site, 35 lesions of epidermolysis bullosa, 36 a colostomy site, 37 and a gunshot wound 38 …”