Basal cell epithelioma arising in a linear epidermal nevus

Horn, M. S.

doi:10.1001/archderm.117.4.247

Cited by 15 publications

(11 citation statements)

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“…However, epithelial tumors arising in the area of NONEEN have rarely been described in the literature. For BCC associated with non-organoid epidermal nevi, approximately 10 cases have been reported so far [6,7,8,9]. Furthermore, the development of squamous cell carcinomas was occasionally observed in epidermal nevi [10].…”

Section: Discussionmentioning

confidence: 99%

Clonality of Basal Cell Carcinoma Arising in an Epidermal Nevus

Hafner

Klein²,

Landthaler³

et al. 2008

Dermatology

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Non-organoid non-epidermolytic (keratinocytic) epidermal nevi are benign congenital skin lesions following the lines of Blaschko. The occurrence of epithelial tumors in epidermal nevi of this type is very rare, and it remains elusive whether these lesions are clonally related or represent a simple collision of independent tumors. We report a case of a patient who developed 2 basal cell carcinomas in an extensive epidermal nevus on the trunk. Molecular analysis of a biopsy containing both basal cell carcinoma and epidermal nevus revealed a PIK3CA mutation. Further analysis suggested that this mutation is present in the basal cell carcinoma rather than in the epidermal nevus. The results favour an independent origin of the basal cell carcinoma, although a possible clonal relationship between both lesions cannot be completely excluded on the basis of the molecular genetic findings.

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Section: Discussionmentioning

confidence: 99%

Clonality of Basal Cell Carcinoma Arising in an Epidermal Nevus

Hafner

Klein²,

Landthaler³

et al. 2008

Dermatology

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“…There are about 13 reports of squamous cell carcinoma [2, 3] and isolated cases of Bowen's disease [4], keratoacanthoma [5], apocrine multifocal papillary adenoma [6] and malignant eccrine poroma [7] arising from verrucous epidermal nevi. There are very few reports describing BCC appearing on verrucous epidermal nevi [8, 9, 10, 11, 12, 13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma Arising on a Verrucous Epidermal Nevus: A Case Report

Viana¹,

Aguinaga²,

Marinho³

et al. 2015

Case Rep Dermatol

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We report a case of basal cell carcinoma that appeared from an epidermal verrucous nevus in a 61-year-old patient. The onset of basal cell carcinoma in sebaceous nevi, basal cell nevi and dysplastic nevi is relatively common, but it is rarely associated with epidermal verrucous nevi. There is no consensus on whether the two lesions have a common cellular origin or whether they merely represent a collision of two distinct tumors. Since this association - as with other malignant tumors - is rare, there is no need for prophylactic removal of epidermal verrucous nevi.

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“…Basal cell carcinoma (BCC),[17] keratoacanthoma,[1819] and squamous cell carcinoma (SCC)[20] have been reported to develop in cutaneous linear epidermal nevus, but this appears to be an extremely rare event. Ichikawa et al [21] reported 16 cases of linear epidermal nevi associated with malignant change (BCC, SCC, Bowen's disease, verrucous carcinoma, adnexal carcinoma).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

2012

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Epidermal nevi are hamartomatous lesions that are typically present at birth, but can occur anytime during childhood and may rarely appear in adulthood. An estimated one-third of individuals with epidermal nevi have involvement of other organ systems; hence, this condition is considered to be an epidermal nevus syndrome. There are four distinct epidermal nevus syndromes recognizable by the different types of associated epithelial nevi: linear sebaceous nevi, linear nevus comedonicus, linear epidermal nevus, and inflammatory linear verrucous epidermal nevus (ILVEN). Each type may be regarded as a part of a syndrome with other systemic manifestations. We report a rare case of ILVEN syndrome in a 23-year-old female patient with a wide spectrum of mucosal, cutaneous, and skeletal abnormalities, demonstrating the polymorphic presentation of this condition.

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Basal cell epithelioma arising in a linear epidermal nevus

Cited by 15 publications

References 0 publications

Clonality of Basal Cell Carcinoma Arising in an Epidermal Nevus

Clonality of Basal Cell Carcinoma Arising in an Epidermal Nevus

Basal Cell Carcinoma Arising on a Verrucous Epidermal Nevus: A Case Report

Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

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