Basal Cell Carcinoma with Sarcomatoid Features (Sarcomatoid Carcinoma): Report of a Case and Review of the Literature

Gómez-Espejo, C; Herrera-Sabal, Alberto; Ríos-Martín, Juan José; Camacho‐Martínez, F.

doi:10.1111/j.1346-8138.2003.tb00430.x

Cited by 28 publications

(19 citation statements)

References 16 publications

(15 reference statements)

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“…In most other cutaneous sarcomatoid carcinomas, however, specific lines of mesenchymal differentiation are not identified and the sarcomatous component resembles atypical fibroxanthoma or high-grade pleomorphic sarcoma. 3,6,14,16,18,19,23,26,33,44 We described some histological findings that have not been reported in the previously published cases of cutaneous sarcomatoid carcinomas. Three of our tumors had predominant malignant giant cell tumor-like tumor components.…”

Section: Discussionmentioning

confidence: 46%

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Menamin

Goh

Poblet

et al. 2006

American Journal of Surgical Pathology

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Primary cutaneous carcinomas rarely show heterologous malignant mesenchymal differentiation. We report 11 cases of sarcomatoid basal cell carcinoma (BCC) with osteosarcomatous differentiation. The patients (7 men and 4 women) ranged in age from 61 to 92 years (median 75 y). The tumors presented as exophytic nodules (0.3 to 7 cm) on the head (n=6), upper limb (n=3), and lower limb (n=2). All lesions were completely excised. Seven patients were alive without evidence of disease (follow-up interval 5 to 24 mo) and 1 patient died of unrelated causes at 7 months without evidence of disease. On histology, the tumors were dermal in location with 2 cases showing focal subcutaneous involvement. Ten tumors were well-circumscribed and 1 tumor showed focally infiltrative edges. Ten tumors revealed conventional BCC associated with varying proportions of osteosarcomatous and undifferentiated sarcomatous stroma. Transition from neoplastic epithelial to mesenchymal cells was seen in 8 cases. One case showed a purely osteoclastic giant cell rich malignant mesenchyme, interpreted as representing early stages of osteosarcomatous transformation. Previously unreported in sarcomatoid BCC, the mesenchymal component of another two cases displayed predominant malignant giant cell tumor like areas and 1 further case disclosed areas reminiscent of telangiectatic osteosarcoma. Pancytokeratins (AE1/3 and MNF116) and smooth muscle actin stained occasional undifferentiated sarcomatous cells in 2 and 3 tumors, respectively. MNF116 and EMA were focally positive in osteosarcomatous tumor cells of 1 case. Although the follow-up interval is short, our data suggest an excellent prognosis for polypoid and exophytic sarcomatoid BCC after complete surgical resection.

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Section: Discussionmentioning

confidence: 46%

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Menamin

Goh

Poblet

et al. 2006

American Journal of Surgical Pathology

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“…In the reported cases, the epithelial component has been predominantly squamous cell and BCCs, and less frequently adnexal and Merkel cell carcinomas . Including this case, 47 cases of basal cell carcinosarcomas have been reported …”

Section: Discussionmentioning

confidence: 82%

Cutaneous basal cell carcinosarcoma: case report and literature review

et al. 2015

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Carcinosarcomas are malignant neoplasms with biphasic carcinomatous and sarcomatous or sarcoma-like components. In general, the sarcomatous component is accepted to be the result of divergent mesenchymal differentiation of the epithelial component. Although well characterized in some anatomic locations (e.g. uterus, upper aerodigestive tract and lung), carcinosarcomas of the skin are rare. Reported epithelial components include squamous, adnexal, neuroendocrine and basaloid. Including this case, only 47 cases of primary cutaneous basal cell carcinosarcoma have been reported in the literature to date. We performed an extensive immunophenotypic evaluation in our case, which confirmed the previously reported coexpression of p53 in both components, and revealed a hitherto unreported coexpression of p16 and p63. Additionally, this report reviews the clinical, pathologic, immunophenotypic characteristics and outcomes of the basal cell carcinosarcomas reported in the literature, in order to emphasize the overall uniform characteristics and clinical behavior of this neoplasm.

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“…This theory was supported by the demonstration of p53 tumor suppressor gene mutation both in epithelial and mesenchymal components. P53, AE1 and AE3 are proven to have high sensitivity in the diagnosis of carcinosarcomas (6).…”

Section: Discussionmentioning

confidence: 99%

Auricular Helix Carcinosarcoma; an Aggressive Tumor Characterized: Case Report

Bilici¹,

Akpınar²,

Yiğit³

et al. 2013

Istanbul Med J

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Primer kutanöz karsinosarkom, epiteliyal ve mezenşimal komponentleri olan sıklıkla vücüdun güneş ışığına maruz kalan baş boyun ve üst ekstremite gibi bölgelerinde görülen bifazik bir tümördür. Daha çok yaşlı erkeklerde görülür ve oldukça nadirdir. Günümüzde histogenezisi hala tartışmalı olan bu tümörün tanısı immunhistokimyasal değerlendirme ile konur. Tümörün epiteliyal komponentleri daha çok squamöz hücreli karsinom, bazal hücreli karsinom ve adneksal tümörler iken, mezenşimal komponentleri pleomorfik sarkoma, atipik fibroksantoma ve osteosarkomadır. Literatürde çok az sayıda bildirilen aurikula heliks karsinosarkom vakalarına katkıda bulunmak amacıyla bir yıl önce aurikula heliksinden total eksize edilen karsinosarkom olgusunun parotis metastazını sunuyoruz. Hastaya total parotidektomi ve modifiye radikal boyun diseksiyonu tip 2 yapılmıştır. Hastanın genel durumu kemoterapi alması için uygun olmamıştır. Postoperatif 25 seans adjuvan radyoterapi yapılan hastanın takiplerinde tümör agresif bir seyir göstermiş ve altıncı ay içinde temporomandibular bölgede rekürrens saptanmıştır. Bunun üzerine hastaya 25 seans daha radyoterapi uygulanmış ve hasta 11. ayda eks olmuştur.Anahtar Kelimeler: Koter Karsinosarkom, aurikula heliks, epiteliyal komponent, mezenkimal komponent Primary cutaneous carcinoma is a dermal biphasic tumor that is more commonly encountered in the upper extremities and the head and neck region, as a result of sunshine exposure. It is a rare tumor and occurs more frequently in older males. Immunohistochemical evaluation is required for the diagnosis. The epithelial components of the tumor include squamous cell carcinoma, basal cell carcinoma and adnexial tumors; mesenchymal components are pleomorphic sarcoma, atypical fibroxanthoma and osteosarcoma. We present a rare case where auricular helix carcinosarcoma metastasized to the parotid gland within the first year following total excision. The patient had a total parotidectomy as well as a modified radical neck dissection type II and postoperative adjuvant radiotherapy. In spite of the surgery and radiotherapy, the tumor had an aggressive course, with recurrence in the temporomandibular region, and the patient was lost on the 11 th month of the follow-up.

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Basal Cell Carcinoma with Sarcomatoid Features (Sarcomatoid Carcinoma): Report of a Case and Review of the Literature

Cited by 28 publications

References 16 publications

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Cutaneous basal cell carcinosarcoma: case report and literature review

Auricular Helix Carcinosarcoma; an Aggressive Tumor Characterized: Case Report

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