Barrett’s esophagus: Prevalence and risk factors in patients with chronic GERD in Upper Egypt

Fouad, Yasser; Makhlouf, Madiha M.; Tawfik, Heba Mohamed; Amin, Hussein El; Ghany, Wael Abdel; El-Khayat, Hisham R

doi:10.3748/wjg.15.3511

Cited by 30 publications

(24 citation statements)

References 19 publications

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“…Out of this large pool, only 50 studies met our inclusion criteria with a focus on patients with reflux symptoms and provided sufficient information about sex distribution (Table 4). Twenty-five of the reports originated in Asia [37,, nine in Europe [99][100][101][102][103][104][105][106], seven in the US [56,[107][108][109][110][111][112], two in South America [113][114][115][116], four in African countries [117,118], and one in Canada [15], the studies reported data on 121 267 patients with 50.0 ± 1.2% women (range: 14.7-76.1%; P = 0.45). Considering the more recent emphasis of symptoms rather than endoscopic findings in the definition of GER, we examined time trends by separating studies into 3-year blocks, on the basis of their year of publication.…”

Section: Sex and Endoscopic Findings: Patient Studiesmentioning

confidence: 99%

Reflux and sex

Nusrat

Bielefeldt

2012

European Journal of Gastroenterology & Hepatology

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Gastroesophageal reflux (GER) affects ∼10-20% of American adults. Although symptoms are equally common in men and women, we hypothesized that sex influences diagnostic and therapeutic approaches in patients with GER. PubMed database between 1997 and October 2011 was searched for English language studies describing symptoms, consultative visits, endoscopic findings, use and results of ambulatory pH study, and surgical therapy for GER. Using data from Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, we determined the sex distribution for admissions and reflux surgery between 1997 and 2008. Studies on symptoms or consultative visits did not show sex-specific differences. Even though women are less likely to have esophagitis or Barrett's esophagus, endoscopic studies enrolled as many women as men, and women were more likely to undergo ambulatory pH studies with a female predominance in studies from the US. Surgical GER treatment is more commonly performed in men. However, studies from the US showed an equal sex distribution, with Nationwide Inpatient Sample data demonstrating an increase in women who accounted for 63% of the annual fundoplications in 2008. Despite less common or severe mucosal disease, women are more likely to undergo invasive diagnostic testing. In the US, women are also more likely to undergo antireflux surgery. These results suggest that healthcare-seeking behavior and socioeconomic factors rather than the biology of disease influence the clinical approaches to reflux disease.

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Section: Sex and Endoscopic Findings: Patient Studiesmentioning

confidence: 99%

Reflux and sex

Nusrat

Bielefeldt

2012

European Journal of Gastroenterology & Hepatology

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“…There is a known context of chronic gastroesophageal or duodenogastroesophageal reflux, reflux esophagitis, epithelial metaplasia (Barrett's esophagus), dysplasia, and adenocarcinoma of the distal esophagus [5,11]. Furthermore, we have found an increase in the incidence of both reflux disease and adenocarcinoma [12], making the disease and its treatment even more relevant.…”

Section: Discussionmentioning

confidence: 86%

Is Toupet fundoplication the procedure of choice for treating gastroesophageal reflux disease? Results of a prospective randomized experimental trial comparing three major antireflux operations in a porcine model

et al. 2011

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Total fundoplication and posterior hemifundoplication are potent operations for the treatment of GERD. Anterior hemifundoplication reduces the reflux as well, but the effects are significantly less than with total and posterior fundoplication. Pharmacologic stimulation showed excellent results after posterior hemifundoplication, and a tendency to overcorrection was shown after total fundoplication.

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“…In the studies performed on patients with GERD or any gastrointestinal system complaint in the countries to the east of Turkey, the prevalence of ERD was between 3.4% and 66.5% (37,38) and the histopathological prevalence of BE was between 0.3% and 7.3% (39)(40)(41)(42)(43). On the other hand, in a study conducted in Japan, the rate of patients that were endoscopically diagnosed with BE was reported to be 37.6%.…”

Section: The Epidemiology Of Gerd Complications In Turkey and Around mentioning

confidence: 99%

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

Bor

Yüksel

2017

Turk J Gastroenterol

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Although many studies are conducted on gastroesophageal reflux disease (GERD) and its complications, the questionnaires and reflux definitions used in the studies are different. Mayo, GERD-Q, DIGEST-Q, RDQ, and various other questionnaires that were created and have been used in the studies. The GERD definition that is mostly accepted around the world is the presence of the complaints of heartburn and/or regurgitation at least once a week. However, many different definitions, such as the presence of heartburn and/or regurgitation at least twice a week or at least once a year (if once a week, "frequent"; if once a year, "rare") and the presence of heartburn and/or regurgitation without considering the frequency and severity, were all used in the studies. Therefore, it is quite difficult to obtain a single datum by collecting these studies. However, studies including all questionnaires and reflux definitions were considered while collecting this data.Another problem encountered while performing epidemiological scanning of GERD is that when the world was separated into two parts as the East and the West, some countries that were different from each other were included in the same group (such as Iran-China and Germany-Brazil). Even though continents are considered for this separation, countries that do not resemble each other from any perspective, such as Iran and China, were included in the same group. Therefore, groups must be formed according to the higher number of ethnic distributions. There are also regional epidemiological differences even in the same country. Moreover, there is no term equivalent to heartburn and regurgitation in some Eastern languages.Turkey is geographically located in the middle of the Eastern and Western countries and the epidemiology of GERD and its complications is similar to both geographical groups (Figure 1). In the Eastern countries, the prevalence of GERD is lower and regurgitation is predominant. On the other hand, in the Western countries, the prevalence of GERD is higher and heartburn is predominant. Considering the complications, erosive esophagitis, Barrett's esophagus, and associated esophageal adenocarcinoma are seen in the Western countries more commonly.In GERD epidemiological studies performed in Turkey, the Mayo questionnaire was mostly used (1, 2). The GERD-Q form was used in one study (3). The studies in which the Mayo questionnaire was used, found the prevalence of GERD as 20% (1), 19.3% (2), 12.5% (4), and 22.8% (5,6), respectively. In the study using the other question form, the prevalence of GERD was 24.7% (3). When 5 studies were evaluated cumulatively, the prevalence was calculated to be 23%. It was observed that regurgitation was predominant in all of the studies. In the cumulative evaluation, the rate of prevalence was 23% for regurgitation and 19% for heartburn.While the date of the publications on the epidemiology of GERD goes back to the 2000s in the countries to the east of Turkey, the first articles on this subject were written in 1990s in the Western cou...

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Barrett’s esophagus: Prevalence and risk factors in patients with chronic GERD in Upper Egypt

Cited by 30 publications

References 19 publications

Reflux and sex

Reflux and sex

Is Toupet fundoplication the procedure of choice for treating gastroesophageal reflux disease? Results of a prospective randomized experimental trial comparing three major antireflux operations in a porcine model

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

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