Barbituric Acids A Review of Preparation, Reactions and Biological Applications

Abstract

Barbiturates, which are derived from the medically significant substance barbituric acid also known as malonylurea or 4-hydroxyuracil, are employed as anaesthetics, sedative-hypnotics, anticonvulsants, and depressants of the central nervous system. In recent years, researchers have paid great attention to compounds and derivatives of barbituric acid, although the first barbituric acid was discovered in 1864 by Adolf Von Baeyer. Due to its great medical and biological importance and wide applications in polymerization catalysts, plastics and textiles, aqueous or oil inks, and polymers. The background, reactions, and methods of preparing barbituric acid have been studied over the last ten years.

Synthesis, Characterization, and Antimicrobial Evaluation of New Heterocyclic Compounds Bearing a Biologically Active Sulfadiazine Moiety

“…Thiazole combined with other chemical compounds produces significant biologically potent derivatives that have been reported to exhibit a wide spectrum of biological activities such as antimicrobial, anti-inflammatory, antioxidant, analgesic, anticancer, antiviral, anti-HIV, antidiabetic, anticonvulsant, antimalarial and antitubercular (Mech et al, 2021, Osmaniye et al, 2018, Tratrat et al, 2022. On the other hand, Sulfadiazine is considered as one of the most important antibiotics that is used in treatment of many diseases such as urinary tract infections (UTIs), toxoplasmosis, malaria (Fahad et al, 2021). Sulfadiazine compounds with guanidinyl functionality showed excellent antituberculosis activity, the resonance stabilization of guanidine group was mainly responsible for the observed activity and different groups on N-substituted phenyl rings of guanidinyl influence the activity (BHAT et al, 2018).…”