Barberry Treatment Reduces Serum Anti-Heat Shock Protein 27 and 60 Antibody Titres and High-sensitivity C-reactive Protein in Patients with Metabolic Syndrome: A Double-blind, Randomized Placebo-controlled Trial

Abstract

Metabolic syndrome is an important risk factor for cardiovascular disease (CVD). The heat shock proteins (HSPs) are associated with risk factors for CVD. The aim of the present study was to survey the effect of barberry on antibody titres to HSPs and high-sensitivity C-reactive protein (hs-CRP) in patients with metabolic syndrome. In our study, subjects (N=106, 79 women and 27 men, 18-65 years old) with metabolic syndrome were randomized into two groups: a group of patients who received three capsules of barberry and a control group who received three capsules of placebo for 6 weeks. Antibodies against HSPs 27, 60/65 and 70, hs-CRP and lipid profile were determined in patients before (week 0) and after (week 6) intervention. spss software (version 16.0; Inc, Chicago, IL) was used for data analysis. Results showed that barberry had no significant effect on serum level of anti-HSPs 65 and 70. But there was a significant decrease in anti-HSP 27 in both case and control groups (p=0.001 and p<0.001, respectively, in the case and control groups). Barberry decreased significantly anti-HSP 60 in the case group (p=0.03). High-sensitivity CRP was decreased non-significantly (p=0.17) in the case group and increased significantly (p=0.04) in the control group. Barberry decreased significantly low-density lipoprotein and total cholesterol and increased significantly high-density cholesterol (p<0.05). Results of the present study suggested that barberry supplementation in patients with metabolic syndrome decreased significantly anti-HSPs 27 and 60 and hs-CRP levels and improved lipid profile.

Relationship between serum anti-heat shock protein 27 antibody levels and obesity

“…There is growing body of data suggesting the important role of this marker in CAD and stroke (12)(13)(16)(17)(18). In the present study, we also investigated its relationship with age.…”

Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open‐labeled, Controlled Study

“…This study is one of the first studies to document the effects of flaxseed supplementation in ameliorating central obesity and MetS. In previous interventional studies, the beneficial effects of some dietary elements on MetS components have been shown (Akaberi and Hosseinzadeh, ; Yang et al ., ; Hosseini and Hosseinzadeh, ; Jeong et al ., ; Zilaee et al ., ; Razavi and Hosseinzadeh, ; Yang et al ., ); however, none of these dietary agents could affect all components of the MetS significantly. In this study, using flaxseed supplementation exacerbated the effect of a low intensive lifestyle modification, which can be adhered for a lifelong duration.…”

Berberine and barberry (Berberis vulgaris): A clinical review

“…In a randomized double‐blind clinical trial in 106 subjects with metabolic syndrome, administration of three capsules of barberry (containing 200 mg of dried barberry) for 6 weeks significantly improved lipid profile and decreased anti‐HSPs 27 and 60 and hs‐CRP levels (Zilaee et al, ). Barberry supplementation also caused a significant reduction in pro‐oxidant–antioxidant balance in these patients (Mohammadi et al, ).…”