Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis

Cifuentes, Lorena; Gattini, Daniela; Torres‐Robles, Romina; Gana, Juan Cristóbal

doi:10.1002/14651858.cd011561.pub2

Cited by 8 publications

(2 citation statements)

References 66 publications

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“…e pathogenesis of cirrhosis UGIB is mainly related to cirrhosis portal hypertension, impaired liver function, coagulation-anticoagulation mechanism disorders, and portal vein internal diameter, when cirrhosis continues to progress into the decompensated stage, it will destroy the normal liver blood sinusoidal structure and function, affecting the portal blood return, prompting the tissue pressure to increase, the internal diameter due to blood stasis widening, forming the esophagogastric fundus. e more severe the injury, the more serious the destruction of the normal structure of the blood sinusoids will be, leading to the accumulation of blood in the upper gastric collateral circulation and the formation of esophageal varices and the occurrence of UGIB [10]. For patients with cirrhotic UGIB, clinical treatment principles are based on hemostasis and reduction of portal vein pressure, prevention and control of complications, and prolongation of survival, with pharmacological treatment strategies preferred.…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin C Combined with Growth Inhibitors on Gastrointestinal Bleeding in Cirrhosis

Wang

Peng

2022

Contrast Media & Molecular Imaging

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The purpose of this study was to investigate the effect of vitamin C combined with growth inhibitors on serum miR-130a, nitric oxide (NO), and hemostasis in the treatment of upper gastrointestinal bleeding (UGIB) in cirrhosis. Eighty patients with cirrhosis UGIB treated in our hospital from March 2021 to March 2022 were selected and divided into two groups using the random number table method. The control group received growth inhibitor treatment, while the observation group was given vitamin C combined with growth inhibitor treatment for 3 d. The hemostatic effect, serum laboratory indexes (miR-130a, NO), liver function indexes (aspartate aminotransferase (AST), alanine aminotransferase (ALT)), adverse effects, and 24 h hemostasis rate were compared between the two groups. The hemostasis time in the observation group was shorter than that in the control group, and the blood transfusion volume was lower than that in the control group. There was no statistical difference regarding the portal blood flow, miR-130a, NO, AST, and ALT indexes between the two groups before treatment. After treatment, the portal blood flow, miR-130a, NO, AST, and ALT indexes in both groups were lower than those before treatment, and all of them were lower in the observation group than in the control group. Adverse reactions showed no significant difference between the two groups of patients with cirrhosis UGIB,, while the 24 h hemostasis rate in the observation group (97.50%) was significantly higher than that in the control group (77.50%). Vitamin C combined with growth inhibitor was effective in the treatment of cirrhotic UGIB, which could effectively shorten the hemostasis time, reduce the transfusion volume and portal blood flow, and improve miR-130a, NO, and liver function levels of patients, with higher safety, and is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Effects of Vitamin C Combined with Growth Inhibitors on Gastrointestinal Bleeding in Cirrhosis

Wang

Peng

2022

Contrast Media & Molecular Imaging

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“…[4][5][6][7] Guidelines on the diagnosis and management of variceal hemorrhage in children with cirrhosis, while controversial, have been the subject of numerous reviews and will not be reviewed here; we refer readers to the references provided for additional information on this topic. [8][9][10][11][12][13] However, there is a paucity of literature on approaches to the diagnosis and management of other complications of PHTN in children with cirrhosis. The aim of this review is to summarize the current guidelines on the diagnosis and management of complications of cirrhotic PHTN in adults and present the most recent data in pediatrics.…”

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confidence: 99%

Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics

et al. 2022

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Complications of cirrhotic portal hypertension (PHTN) in children are broad and include clinical manifestations ranging from variceal hemorrhage, hepatic encephalopathy (HE), ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS) to less common conditions such as hepatopulmonary syndrome, portopulmonary hypertension, and cirrhotic cardiomyopathy. The approaches to the diagnosis and management of these complications have become standard of practice in adults with cirrhosis with many guidance statements available. However, there is limited literature on the diagnosis and management of these complications of PHTN in children with much of the current guidance available focused on variceal hemorrhage. The aim of this review is to summarize the current literature in adults who experience these complications of cirrhotic PHTN beyond variceal hemorrhage and present the available literature in children, with a focus on diagnosis, management, and liver transplant decision making in children with cirrhosis who develop ascites, SBP, HRS, HE, and cardiopulmonary complications.

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Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis

Cited by 8 publications

References 66 publications

Effects of Vitamin C Combined with Growth Inhibitors on Gastrointestinal Bleeding in Cirrhosis

Effects of Vitamin C Combined with Growth Inhibitors on Gastrointestinal Bleeding in Cirrhosis

Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics

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