Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis

Koytchev, Rossen; Alken, R. G.; Dundarov, S

doi:10.1016/s0944-7113(99)80013-0

Cited by 77 publications

(36 citation statements)

References 3 publications

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“…Melissa leaf has a long history of use as a topical antiviral by herbal practitioners and it is variously used directly on the skin, or as either a 1% tincture in cream, or dried aqueous extract in cream (1,2 (6)(7)(8).These trials involved treating lesions within 72 hours of the first symptoms, 2-4 times daily for 5-10 days, with a cream containing 1% of a lyophilised aqueous extract from dried Melissa leaf (70:1). One trial concluded that recurrence-free intervals were extended in comparison with topical virustatic preparations containing idoxuridine and tromantidine hydrochloride (9).…”

Section: Introductionmentioning

confidence: 99%

Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)

et al. 2007

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Purpose. To measure the rosmarinic acid content of eight commercial tinctures derived from fresh (n= 5) and dried (n=3) Melissa officinalis herb. Methods. Rosmarinic acid and the internal standard (esculin) were purchased from Aldrich Chemical Co. The column used was a Luna C18, 5 um (150 x 4.6 mm I.D., Phenomenex) maintained at ambient room temperature. The HPLC system consisted of a Shimadzu SCL-6B controller, Shimadzu LC-6A pumps, Shimadzu SPD-6A UV single wavelength spectrophotometric detector set to 320 nm and Shimadzu SIL-6B autosampler. Gradient elution of the samples and standard were performed using ammonium formate (0.02 M; pH 6.25 at 27 oC; eluent A) and methanol (eluent B). The gradient elution initial conditions were 2% of eluent B with linear gradient to 60% at 30 min, followed by linear gradient to 90% of eluent B at 31 min, this proportion being maintained for 4 min. The column was then returned to the initial condition at 36 min and maintained until the end of the run at 43 min. The flow rate was 1 mL/min. The assay was validated for sensitivity, accuracy and reproducibility. Results. The content of rosmarinic acid in commercial tinctures was significantly higher in the tinctures made from dried plant material (2.96 – 22.18 mg/mL) compared to fresh plant tinctures (

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Section: Introductionmentioning

confidence: 99%

Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)

et al. 2007

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“…El extracto de Melissa officinalis es utilizado ampliamente para diversos procedimientos clínicos, particularmente para el control de la ansiedad y sintomatologías similares, sin embargo, sus propiedades antivirales poseen un efecto de remisión sobre el VHS-1 y HSV-2 (Nolkemper et al), siendo evaluado en investigaciones microbiológicas previas (Koytchev et al, 1999), aunque generalmente en estudios in vitro (Astani et al, 2012) La utilización del extracto de Melissa officinalis en crema para la evaluación de la remisión del herpes simple evidenció la disminución de los días de infección de forma sostenida en el periodo de evaluación, coincidiendo con investigaciones que sitúan dicho efecto a los 2 días de uso (Koytchev et al) extiendo los resultados a la sintomatología asociada.…”

Section: Discussionunclassified

Estudio Comparativo entre Terapia con Melissa officinalis vs. Tratamiento Convencional con Aciclovir Tópico al 5% para Lesiones Herpéticas Tipo 1

2014

Int. J. Odontostomat.

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entre terapia con Melissa officinalis vs. tratamiento convencional con aciclovir tópico al 5% para lesiones herpéticas tipo 1. Int. J. Odontostomat., 8(3):323-328, 2014. RESUMEN:El herpes simple tipo I es una patología infecciosa e inflamatoria de tipo vírico que se caracteriza por la aparición de lesiones ulcerativas extra orales, de duración aproximada de 14 días y que provocan gran picazón e incomodidad a las personas que lo padecen. El objetivo de este trabajo fue evaluar el uso la Melissa officinalis (toronjil) como terapia alternativa sobre el tiempo de remisión y el número de las lesiones extraorales en pacientes con herpes simple del comparado con el Aciclovir tópico al 5% como terapia convencional. Se realizó un ensayo clínico, aleatorizado y enmascarado simple, controlado. Se evaluó a 34 pacientes con lesiones herpéticas extra orales activas en la etapa primaria vesiculosa, sin patologías asociadas a alteraciones del sistema inmunológico como diabetes mellitus, alergias e hipertensión arterial. Se les administró el tratamiento tópico y se les evalúo diariamente las lesiones herpéticas. La Melissa officinalis posee un efecto antiviral sobre lesiones herpéticas tipo 1 al igual que el Aciclovir tópico al 5%, pero la Melissa officinalis es más efectivo en la disminución de días con lesiones herpéticas (valor p=0,05). La Melissa officinalis tiene un efecto antiviral positivo sobre lesiones herpéticas tipo 1, disminuyendo el número total de días con las lesiones herpéticas en comparación con el Aciclovir tópico al 5%.PALABRAS CLAVE: herpes simple tipo 1, patología viral, lesiones ulcerativas, Melissa officinalis, aciclovir tópico al 5%, antiviral.

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“…Vahabpour-Roudsari R et al is a plant growing in various areas, incluing the Mediterranean region and western Asia (8,9). The extract of Lemon Balm L. (Lamiaceae) has been reported to inhibit protein synthesis (10).…”

Section: A R C H I V E O F S I Dmentioning

confidence: 99%

Evaluation of Potential Antiviral Activity of the Hydroalcoholic Extract of Lemon Balm L. against Herpes Simplex Virus Type 1

et al. 2010

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Background and Aims: Lemon Balm L (Lamiaceae) has been used in a variety of practical applications in medical sciences. Its antiviral activity against herpes simplex virus type-1 (HSV-1) was investigated in cell culture. Lemon Balm hydroalcoholic extract was found to be non-toxic to Vero cells up to concentration 800 ug/ml and inhibited the growth and development of HSV-1 in dose-dependent manner in Vero cells. Methods: In order to study the possible mechanisms of the antiviral activity of Lemon Balm extract, cells were treated with extract before, during and after infection, and the viral titers were tested by TCID50 assay. Results: The antiviral effects in treatment of post and during virus infection were more remarkable than the treatment of preinfection. For further investigation indirect immunofluorescence technique was used to elucidate the antiviral mechanism of the extract by infecting Vero cells at different times and monitoring the synthesis of viral proteins. Conclusion: Although the precise mechanism has not yet to be defined, our work indicated that lemon Balm L. extract could inhibit growth and development of HSV-1 in cells in vitro.

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Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis

Cited by 77 publications

References 3 publications

Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)

Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)

Estudio Comparativo entre Terapia con Melissa officinalis vs. Tratamiento Convencional con Aciclovir Tópico al 5% para Lesiones Herpéticas Tipo 1

Evaluation of Potential Antiviral Activity of the Hydroalcoholic Extract of Lemon Balm L. against Herpes Simplex Virus Type 1

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