Balancing Safety and Potential for Impact in Universal Iron Interventions

Baldi, Andrew; Larson, Leila M; Pasricha, Sant‐Rayn

doi:10.1159/000503356

Cited by 5 publications

(5 citation statements)

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“…Three of the studies on human infants and toddlers reported no effect of supplementation on the Actinobacteria phylum. 92,109,113 On the contrary, a decrease was observed during iron supplementation in infants, 10 in mice, 93 and in the in-vitro model. 96 All three studies that dealt with the effect of iron supplementation on e1874855-12 the Actinobacteria class, Actinobacteriales order, and Bifidobacteriaceae family described a decrease in the proportions, regardless of the model used.…”

Section: The Case Of the Lactobacillaceae Family And The Actinobacteria Phylummentioning

confidence: 95%

“…A detailed analysis of one model also revealed inconsistencies. For example, in humans, an increase, 10 a decrease 91 , and no effect 89,91,109 of iron administration were reported for the phylum Firmicutes (Figure 5). These discrepancies appeared at all taxonomic levels.…”

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

“…Although only half as bioavailable, ferrous sulfate does not undergo physical and sensory changes. 109 The chelated iron complex, ferric sodium ethylenediaminetetraacetate (NaFeEDTA) is frequently used 6,9,10,[89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108] since it is highly bioavailable due to its inert chemical reactivity to lipid peroxidation and resistance to luminal inhibitors such as phytate. 109,110 Nano iron has also been tested as it does not require solubilization in the stomach prior to uptake by enterocytes as whole nanoparticles via endocytosis.…”

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

“…109 The chelated iron complex, ferric sodium ethylenediaminetetraacetate (NaFeEDTA) is frequently used 6,9,10,[89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108] since it is highly bioavailable due to its inert chemical reactivity to lipid peroxidation and resistance to luminal inhibitors such as phytate. 109,110 Nano iron has also been tested as it does not require solubilization in the stomach prior to uptake by enterocytes as whole nanoparticles via endocytosis. 111 The different levels of bioavailability of the different forms of iron used in supplementation and fortification lead to different modulation of the gut microbiota.…”

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

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Iron homeostasis in host and gut bacteria – a complex interrelationship

2021

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Iron deficiency is the most frequent nutritional deficiency in the world with an estimated 1.4 billion people affected. The usual way to fight iron deficiency is iron fortification, but this approach is not always effective and can have undesirable side effects including an increase in the growth and virulence of gut bacterial pathogens responsible for diarrhea and gut inflammation. Iron is mainly absorbed in the duodenum and is tightly regulated in mammals. Unabsorbed iron enters the colonic lumen where many microorganisms, referred to as gut microbiota, reside. Iron is essential for these bacteria, and its availability consequently affects this microbial ecosystem. The aim of this review is to provide further insights into the complex relationship between iron and gut microbiota. Given that overcoming anemia caused by iron deficiency is still a challenge today, gut microbiota could help identify more efficient ways to tackle this public health problem.

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Section: The Case Of the Lactobacillaceae Family And The Actinobacteria Phylummentioning

confidence: 95%

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

Section: Effect Of Iron Supplementation On Gut Bacterial Compositionmentioning

confidence: 99%

See 2 more Smart Citations

Iron homeostasis in host and gut bacteria – a complex interrelationship

2021

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“…One of the few consistent results is the decrease in the proportion of bacteria of the phylum Actinobacteria in case of iron-deficiency anemia (64). In the case of iron supplementation or fortification, the chemical form of iron used (ferrous sulfate, ferrous furamate, NaFeEDTA, ferric sodium ethylenediaminetetraacetate) seems to affect bacterial composition differently (65)(66)(67). Surprisingly, no general trends could be identified, even in the same model and using the same method with iron supplementation (39).…”

Section: Micronutrients and Host Healthmentioning

confidence: 99%

Bacteria from the gut influence the host micronutrient status

Dje Kouadio,

Wieringa,

Greffeuille

et al. 2023

Critical Reviews in Food Science and Nutrition

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Micronutrient malnutrition remains a serious public health problem in most low-and middle income countries, with severe consequences for child physical and psychomotor development. Traditional methods of treatment and prevention, such as supplementation and fortification, have not always proven to be effective and may have undesirable side-effects, including increased growth and virulence of pathogenic gut bacteria, resulting in diarrhea and gut inflammation. Commensal bacteria in the gut have demonstrated the ability to increase the bioavailability of certain micronutrients, notably by removing anti-nutritional compounds, such as phytates and polyphenols, or by the synthesis of vitamins or their derivatives. The intestinal microbiota is also, in symbiosis with the gastrointestinal mucosa, the first line of protection of the internal environment against the external environment. It thus contributes to the reinforcement of the integrity of the intestinal epithelium and to a better absorption of micronutrients. They represent a save alternative to prevent micronutrients deficiencies. However, the metabolic characterization of the intestinal microbiota is not yet complete and its role in micronutrient malnutrition is still poorly understood. The bacterial metabolism is also dependent of micronutrients acquired from the gut environment and resident bacteria may compete or collaborate to maintain micronutrient homeostasis. Gut microbiota composition can therefore be modulated by micronutrient availability. This review brings together current knowledge on this two-Page 2 sur 36 way relationship between micronutrients and gut microbiota bacteria, with a focus on iron, zinc, vitamin A and folate (vitamin B9), which are respectively minerals and vitamins of interest in a global context. key wordsbacteriagut microbiotahumanmicronutrientsdeficiency -prevention 1.

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Anaemia: Worldwide Prevalence and Progress in Reduction

Baldi

Pasricha

2022

Nutrition and Health

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Balancing Safety and Potential for Impact in Universal Iron Interventions

Cited by 5 publications

References 0 publications

Iron homeostasis in host and gut bacteria – a complex interrelationship

Iron homeostasis in host and gut bacteria – a complex interrelationship

Bacteria from the gut influence the host micronutrient status

Anaemia: Worldwide Prevalence and Progress in Reduction

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